4.2.1.107: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase

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For detailed information about 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase, go to the full flat file.

Reaction

(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA

Synonyms

46 kDa hydratase, 46 kDa hydratase 2, perMFE-2

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.107 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase

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Results	in table
90	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
1	General Information
1	General Stability
5	Localization
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
6	Organism
5	Pathway
2	PDB ID
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reaction Type
6	Reference
5	Source Tissue
1	Specific Activity [micromol/min/mg]
6	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 4.2.1.107 - 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase

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(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O

(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA

Homo sapiens

reaction in cholic acid synthesis is catalyzed by peroxisomal multifunctional enzyme type 2. Human perMFE-2 is induced by transcription factors AP2alpha and AP2gamma and attenuated by Sp1 binding to recognition sequence located within and -151/-142 region

657721