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4.2.1.106: bile-acid 7alpha-dehydratase

This is an abbreviated version!
For detailed information about bile-acid 7alpha-dehydratase, go to the full flat file.

Word Map on EC 4.2.1.106

Reaction

7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA
=
12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA
+
H2O

Synonyms

baiE

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.106 bile-acid 7alpha-dehydratase

Engineering

Engineering on EC 4.2.1.106 - bile-acid 7alpha-dehydratase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D106N
inactive mutant
R146Q
inactive mutant
Y126F
strongly reduced activity compared to wild type
Y54F
reduced activity compared to wild type
D106N
-
inactive mutant
-
D35N
-
inactive mutant
-
Y30F
-
inactive mutant
-
Y54A
-
inactive mutant
-
Y54F
-
reduced activity compared to wild type
-