4.2.1.104: cyanase
This is an abbreviated version!
For detailed information about cyanase, go to the full flat file.
Word Map on EC 4.2.1.104
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4.2.1.104
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bicarbonate
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bicarbonate-dependent
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anderson
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fuchs
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pseudoalcaligenes
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molecular biology
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nitrospira
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decameric
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environmental protection
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biotechnology
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drug development
- 4.2.1.104
- bicarbonate
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bicarbonate-dependent
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anderson
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fuchs
- pseudoalcaligenes
- molecular biology
- nitrospira
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decameric
- environmental protection
- biotechnology
- drug development
Reaction
Synonyms
107368746, AtCYN, cyanase, cyanate aminohydrolase, cyanate C-N-lyase, cyanate hydratase, cyanate hydrolase, cyanate lyase, CYN, CynS, EC 3.5.5.3, EC 4.3.99.1, Hydrolase, cyanate, Ngar_c31480, NITMOv2_1274, OsCYN, slr0899, SpCynS, Spro_1533, tetur28g02430
ECTree
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General Information
General Information on EC 4.2.1.104 - cyanase
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evolution
malfunction
physiological function
additional information
an ancient gene transfer occurred before the diversification within the Tetranychidae family
evolution
genomic and transcriptomic analysis, phyloegentic analysis, the cyanase gene originates from a single horizontal gene transfer event, which precedes subsequent speciation, comparison of prokaryotic cyanases to eukaryotic cyanase from Tetranychus urticae, which all form homodecamers and have conserved active site residues, but display different surface areas between homodimers in the overall decameric structure
evolution
phylogenetic relationship of Nitrososphaera gargensis cyanase with the Nitrospira cyanases, overview
evolution
while Nitrososphaera gargensis is the only ammonia-oxidizing microbe with a sequenced genome in which a cyanase is present that is likely acquired from a Nitrospira strain via lateral gene transfer, all nitrite-oxidizers for which a genome sequence is available contain a gene annotated as cyanase. Phylogenetic relationship of Nitrososphaera gargensis cyanase with the Nitrospira cyanases, overview
evolution
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while Nitrososphaera gargensis is the only ammonia-oxidizing microbe with a sequenced genome in which a cyanase is present that is likely acquired from a Nitrospira strain via lateral gene transfer, all nitrite-oxidizers for which a genome sequence is available contain a gene annotated as cyanase. Phylogenetic relationship of Nitrososphaera gargensis cyanase with the Nitrospira cyanases, overview
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cyanate treatment inhibits germination and early seedling growth of Cyn knockout mutant plants, while wild-type plants show resistance to cyanate stress
malfunction
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cyanate treatment inhibits germination and early seedling growth of Cyn knockout mutant plants, while wild-type plants show resistance to cyanate stress
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the CHa12 peptide derived from cyanate hydratase inhibits the growth of Porphyromonas gingivalis in a dose-dependent manner, cyanate hydratase shows Rgp/Kgp inhibitory activities
physiological function
one role of cyanases in plants is detoxification, plants containing CYN exhibit resistance to KCNO stress
physiological function
one role of cyanases in plants is detoxification, plants containing CYN exhibit resistance to KCNO stress. The conserved residues Ser117 and Glu94 are not only catalytic residues in AtCYN but also contribute to the stability of AtCYN homodecamers. Transcriptional regulation and expression pattern of AtCYN, overview
physiological function
cyanase catalyzes the detoxification of cyanate
physiological function
cyanase enzyme converts cyanate into CO2 and NH3 in a bicarbonate-dependent reaction. At low cyanate concentrations, the endogenous plant cyanases play a vital role in cyanate detoxification
physiological function
cyanate hydratase (CynS) catalyzes the decomposition of cyanate and bicarbonate into ammonia and carbon dioxide
physiological function
Nitrospira moscoviensis cells are capable of cyanate degradation in vivo
physiological function
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one role of cyanases in plants is detoxification, plants containing CYN exhibit resistance to KCNO stress. The conserved residues Ser117 and Glu94 are not only catalytic residues in AtCYN but also contribute to the stability of AtCYN homodecamers. Transcriptional regulation and expression pattern of AtCYN, overview
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physiological function
Synechocystis sp. PCC 6803 Kazusa
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cyanase enzyme converts cyanate into CO2 and NH3 in a bicarbonate-dependent reaction. At low cyanate concentrations, the endogenous plant cyanases play a vital role in cyanate detoxification
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physiological function
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cyanate hydratase (CynS) catalyzes the decomposition of cyanate and bicarbonate into ammonia and carbon dioxide
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transcriptional regulation of cynS expression, overview
additional information
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transcriptional regulation of cynS expression, overview
additional information
transcriptional regulation of cynS expression, overview
additional information
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transcriptional regulation of cynS expression, overview
additional information
ammonia release assay, pigment contents, and total carbohydrate measurements of transgenic Arabidopsis thaliana plants expressing the enzyme, overview. Transgenic Arabidopsis thaliana plants expressing the enzyme are exposed to cyanate, either applied by foliar spray or supplemented in growth medium, and show less reduction in pigment contents, antioxidant enzymes, carbohydrate contents, and reduced levels of plant growth retardation. Plant growth assays under cyanate stress show enhanced growth and biomass accumulation in cyanase overexpressors compared to control plants
additional information
glycerol molecules bound at the entry to the active site of the enzyme during crystallization indicate conserved residues that might be important for the trafficking of substrates and products. The enzyme binds specifically to DNA
additional information
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glycerol molecules bound at the entry to the active site of the enzyme during crystallization indicate conserved residues that might be important for the trafficking of substrates and products. The enzyme binds specifically to DNA
additional information
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transcriptional regulation of cynS expression, overview
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additional information
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transcriptional regulation of cynS expression, overview
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additional information
Synechocystis sp. PCC 6803 Kazusa
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ammonia release assay, pigment contents, and total carbohydrate measurements of transgenic Arabidopsis thaliana plants expressing the enzyme, overview. Transgenic Arabidopsis thaliana plants expressing the enzyme are exposed to cyanate, either applied by foliar spray or supplemented in growth medium, and show less reduction in pigment contents, antioxidant enzymes, carbohydrate contents, and reduced levels of plant growth retardation. Plant growth assays under cyanate stress show enhanced growth and biomass accumulation in cyanase overexpressors compared to control plants
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additional information
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glycerol molecules bound at the entry to the active site of the enzyme during crystallization indicate conserved residues that might be important for the trafficking of substrates and products. The enzyme binds specifically to DNA
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