4.2.1.103: cyclohexyl-isocyanide hydratase
This is an abbreviated version!
For detailed information about cyclohexyl-isocyanide hydratase, go to the full flat file.
Word Map on EC 4.2.1.103
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4.2.1.103
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n-substituted
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putida
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deformylase
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pascens
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acclimatization
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arthrobacter
- 4.2.1.103
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n-substituted
- putida
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deformylase
- pascens
-
acclimatization
- arthrobacter
Reaction
Synonyms
cyclohexyl isocyanide hydratase, ICH, InhB, isocyanide hydratase, isonitrile hydratase, More, N-cyclohexylformamide hydro-lyase
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General Information
General Information on EC 4.2.1.103 - cyclohexyl-isocyanide hydratase
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metabolism
physiological function
isonitrile hydratase is involved in the first step of isonitrile metabolism hydrating isonitrile to the corresponding N-substituted formamide
metabolism
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isonitrile hydratase is involved in the first step of isonitrile metabolism hydrating isonitrile to the corresponding N-substituted formamide
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isocyanide hydratase is an enzyme of the DJ-1 superfamily that hydrates isocyanides to yield the corresponding N-formamide, structural basis for catalysis, overview. ICH contains a highly conserved Cys101 that is required for catalysis and interacts with Asp17, Thr102, and an ordered water molecule in the active site. Asp17 activates the ordered water molecule to hydrate organic isocyanides. The thiolate of Cys101 is proposed to be a critical nucleophile that initiates the hydration of isocyanides
physiological function
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isocyanide hydratase is an enzyme of the DJ-1 superfamily that hydrates isocyanides to yield the corresponding N-formamide, structural basis for catalysis, overview. ICH contains a highly conserved Cys101 that is required for catalysis and interacts with Asp17, Thr102, and an ordered water molecule in the active site. Asp17 activates the ordered water molecule to hydrate organic isocyanides. The thiolate of Cys101 is proposed to be a critical nucleophile that initiates the hydration of isocyanides
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