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4.2.1.1: carbonic anhydrase

This is an abbreviated version!
For detailed information about carbonic anhydrase, go to the full flat file.

Word Map on EC 4.2.1.1

Reaction

H2CO3
=
CO2
 +
H2O

Synonyms

(CA) XIV, AaCA1, alkalistable alpha-carbonic anhydrase, alpha carbonic anhydrase, alpha class carbonic anhydrase, alpha-CA, alpha-carbonic anhydrase, alpha-carbonic anhydrase isozyme II, alpha-class carbonic anhydrase, alpha-type CA, alpha-type carbonic anhydrase, alphaCA, alphaCA1, Am CA, AmCA, anhydrase, ASCA, AtCA1, AtCA2, AtCAL1, AtCAL2, B13-CA, BCA II, bCA IV, BCAII, BCAIIGln253Cys, beta carbonic anhydrase, beta-CA, beta-carbonic anhydrase, beta-class carbonic anhydrase, betaCA, betaCA1, BhCA, bovine carbonic anhydrase II, bsCA I, bsCA II, CA, CA 1, CA 3, CA I, CA II, CA III, CA IV, CA IX, CA VA, CA VB, CA VI, CA VII, CA VIII, CA XII, CA XIII, CA XIV, Ca XV, CA-I, CA-II, CA-III, CA-IX, CA-VA, CA-VB, CA-VI, CA-VII, CA-XII, CA-XIV, CA1, CA14x, CA2, CA2 homolog, CA2-like, CA3, CA4, CA5A, CA6, CA9, CAA, CAA1, CAA2, Cab, cab-type beta-class carbonic anhydrase, cadmium carbonic anhydrase, CAH3, CAH7, CAH8, CAI, CAII, CAIII, CAIV, CAIX, Cam, CamH, CaN, Can2, canA, canB, CaNce103, carbonate anhydrase, Carbonate dehydratase, carbonate dehydratase I, carbonate dehydratase III, Carbonate dehydratase IX, Carbonate dehydratase VA, Carbonate dehydratase VB, Carbonate dehydratase VI, Carbonate dehydratase VII, Carbonate dehydratase XII, Carbonate dehydratase XIV, carbonate hydro-lyase, carbonate hydrolase, carbonate hydrolyase, carbonic acid anhydrase, carbonic anhydrase, carbonic anhydrase 1, carbonic anhydrase 14, carbonic anhydrase 2, carbonic anhydrase 3, carbonic anhydrase 5A, carbonic anhydrase 6, carbonic anhydrase 9, carbonic anhydrase cambialistic enzyme, carbonic anhydrase I, carbonic anhydrase I (CA I) Michigan 1, carbonic anhydrase II, carbonic anhydrase III, carbonic anhydrase isozyme I, carbonic anhydrase isozyme II, carbonic anhydrase isozyme III, carbonic anhydrase isozyme IV, carbonic anhydrase isozyme IX, carbonic anhydrase IV, carbonic anhydrase IX, carbonic anhydrase type III, carbonic anhydrase V, carbonic anhydrase VA, carbonic anhydrase VI, carbonic anhydrase VII, carbonic anhydrase XII, carbonic anhydrase XIII, carbonic anhydrase XIV, carbonic anhydrase XV, carbonic anhydrase-I, carbonic anhydrase-II, carbonic anhydrase-related protein, carbonic anhydrase-related protein VIII, carbonic dehydratase, carboxyanhydrase, CARP, CAS1, CAS2, CasCAc, CasCAg, CAV, CAVA, CAXII, CcaA, CcmM, CDCA1, chloroplast carbonic anhydrase, clCA, CmCA, CO2 hydrase, CO2 hydratase, CPB, CpsCA, CpsCAgamma, CrCAH3, CsoSCA, cynT, CynT2, cytoplasmic carbonic anhydrase, Dca, dCA I, dCA II, dCAII, DDCA, dehydratase, carbonate, delta carbonic anhydrase, delta-carbonic anhydrase, delta-class CA, diatom carbonic anhydrase, Dsp-aCAopt sp., dual domain-carbonic anhydrase, dual-domain carbonic anhydrase, DVU_1777, E84A MTCA, eCA, ECCA, erythrocyte carbonic anhydrase, eta-CA, eta-carbonic anhydrase, external carbonic anhydrase, extracellular carbonic anhydrase, FbiCA 1, fCA, gamma carbonic anhydrase 1, gamma carbonic anhydrase 2, gamma carbonic anhydrase-like 1, gamma carbonic anhydrase-like 2, gamma-CA, gamma-CA1, gamma-CA2, gamma-CAL1, gamma-CAL2, gamma-carbonic anhydrase, gamma-class carbonic anhydrase, gammaCA, H216N ATCA, H64A HCA II, HC II, HCA, hCA I, HCA II, hCA III, hCA IV, hCA IX, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, hCA XIV, hCA XIV catalytic domain, HCA-I, HCA-II, hCAII, HcCA3, HICA, HP1186, hpalphaCA, hpbetaCA, human carbonic anhydrase, human carbonic anhydrase I, human carbonic anhydrase II, human carbonic anhydrase III, human carbonic anhydrase isoenzyme I, human carbonic anhydrase isoenzyme II, human carbonic anhydrase IX, human carbonic anhydrase XII, human carbonic anhydrase XIV, Ice-CA, icfA, isozyme CA II, isozyme CA IV, LdcCA, luminal carbonic anhydrase, lwCA, mCA V, mCA XIII, Membrane antigen MN, mesohalophilic carbonic anhydrase, MG-CA, MgaCA, More, mtcA1, mtcA2, MtCam, MTCY373.03, Nce103, NcoCA, NGCA, NstCcmM209, OEC33 protein, P54/58N, pentraxin-CA VI, pentraxin-carbonic anhydrase, PERMA_1443, PF3D7_1140000, PfCAdom, PgiCA, PgiCAb, PGJ_00014320, PhaCAgamma, PhCamH, photosystem II-associated carbonic anhydrase, Pl-can, plant-type (beta-class) carbonic anhydrase, PMCA, pMW1, poly-[Hb-SOD-CAT-CA], polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase, PtCA1, RCC-associated antigen G250, Renal cell carcinoma-associated antigen G250, RT erythrocyte CA, Rv1248, Rv1284, Rv3273, Rv3588c, SABP3, Salivary carbonic anhydrase, SazCA, scCA, Secreted carbonic anhydrase, secretory carbonic anhydrase, secretory carbonic anhydrase VI, SspCA, STPCA, STPCA-2, SULAZ_0541, TacA, TCAb, TCAc, TcCA, Tcru, Tcr_1545, Theam_1576, tobacco salicylic acid-binding protein 3, Tumor antigen HOM-RCC-3.1.3, TWCA1, TweCA, VchCA

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.1 carbonic anhydrase

IC50 Value

IC50 Value on EC 4.2.1.1 - carbonic anhydrase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.2083
(1R,2S,3S,4S)-4,6-diamino-2-([3-O-[(1S,2S,3S,4S,5S)-2-amino-5-(aminomethyl)-3,4-dihydroxycyclohexyl]-alpha-L-arabinofuranosyl]oxy)-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-beta-L-glucopyranoside
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
0.2135
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
-
0.07
(3-chlorophenyl)(2-thioxo-1H-benzo[d]imidazol-1-yl)methanone
Gallus gallus
-
pH 7.4, 37°C
0.00533
(7S)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-3-[[(furan-2-carbonyl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
0.0001
1,3-diacetyl-1H-benzo[d]imidazol-2(3H)-one
Gallus gallus
-
pH 7.4, 37°C
0.005
1,3-diacetylbenzimidazole-2-thione
Gallus gallus
-
pH 7.4, 37°C
0.029
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)-3-phenylpropan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.017
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)ethanone
Gallus gallus
-
pH 7.4, 37°C
0.016
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)hexan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.026
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)propan-1one
Gallus gallus
-
pH 7.4, 37°C
0.025
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)decan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.042
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
Gallus gallus
-
pH 7.4, 37°C
0.017
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexadecan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.029
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.048
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.02
1-(2-Tthioxo-1H-benzo[d]imidazol-1-yl)butan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.012
1-(3-acetyl-1,2-dihydro-2-thioxobenzo[d]imidazol-1-yl)hexan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.019
1-(3-ethyl-1,2-dihydro-2-thioxobenzo[d]imidazole-1-yl)ethanone
Gallus gallus
-
pH 7.4, 37°C
0.0533 - 0.693
1-(4-methoxyphenyl)-2-methyl-3-nitro-1-H-indol-6-ol
0.0161
1-[(aminooxy)sulfinyl]-4-methylbenzene
Saccharomyces cerevisiae
-
-
0.000433
1-[4-[(aminooxy)sulfinyl]phenyl]methanamine
Saccharomyces cerevisiae
-
-
0.05
2,3,4,5,6-pentafluoro-N-(2-sulfamoylphenyl)benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
2,3,4,5,6-pentafluoro-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)benzamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
2,3,4,5,6-pentafluoro-N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]benzamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.000223
2,4-bis[(aminooxy)sulfinyl]-5-(trifluoromethyl)aniline
Saccharomyces cerevisiae
-
-
0.000169
2,4-bis[(aminooxy)sulfinyl]-5-chloroaniline
Saccharomyces cerevisiae
-
-
0.24
2,4-Dichlorophenol
Acipenser gueldenstaedtii
-
pH 7.4, 30°C, inhibition of CO2 hydration activity
0.05
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(2-sulfamoylphenyl)acetamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(3-sulfamoylphenyl)acetamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(4-sulfamoylphenyl)acetamide
Plasmodium falciparum
-
IC50 above 0.05 mM
3.4
2-mercaptoethanol
Halothiobacillus neapolitanus
-
-
0.05
2-oxo-N-(2-sulfamoylphenyl)-2H-chromene-3-carboxamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
2-oxo-N-(3-sulfamoylphenyl)-2H-chromene-3-carboxamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
2-oxo-N-(4-sulfamoylbenzyl)-2H-chromene-3-carboxamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
2-oxo-N-(4-sulfamoylphenyl)-2H-chromene-3-carboxamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3-carboxamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.062
2-phenoxy-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
Gallus gallus
-
pH 7.4, 37°C
0.069
2-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
Gallus gallus
-
pH 7.4, 37°C
0.0000151
2-[(aminooxy)sulfinyl]-5-(2-chlorophenyl)-1,3,4-thiadiazole
Saccharomyces cerevisiae
-
-
0.0123
2-[(aminooxy)sulfinyl]aniline
Saccharomyces cerevisiae
-
-
0.05
2-[(diphenylcarbamoyl)amino]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.000163
2-[4-[(aminooxy)sulfinyl]phenyl]ethanamine
Saccharomyces cerevisiae
-
-
0.00897
2-[4-[(aminooxy)sulfinyl]phenyl]ethanol
Saccharomyces cerevisiae
-
-
0.02
3-cyclohexyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
Gallus gallus
-
pH 7.4, 37°C
3.07 - 4.7
3-methylsalicylic acid
0.024
3-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.000165
3-[4-[(aminooxy)sulfinyl]phenyl]propanoic acid
Saccharomyces cerevisiae
-
-
0.0059 - 0.395
4-(2-phenylacetamido)-3-bromobenzenesulfonamide
0.0081 - 0.061
4-(2-phenylacetamido)-3-chlorobenzenesulfonamide
0.0081 - 0.067
4-(2-phenylacetamido)-3-fluorobenzenesulfonamide
0.0067 - 0.108
4-(2-phenylacetamido)benzenesulfonamide
0.0081 - 0.067
4-(2-phenylacetamidoethyl)benzenesulfonamide
0.0083 - 0.086
4-(2-phenylacetamidomethyl)benzenesulfonamide
0.0068 - 0.075
4-(2-pyridin-2-ylacetamido)benzenesulfonamide
0.0073 - 0.074
4-(2-pyridin-4-ylacetamido)benzenesulfonamide
0.0076 - 0.097
4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide
0.001002
4-(3,4-dichlorophenylureido)thioureido-benzenesulfonamide
Plasmodium falciparum
-
-
0.05
4-(3-[[(1E)-(1-methyl-1H-imidazol-2-yl)methylidene]amino]propyl)benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
4-(carbamothioylamino)benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
4-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.003886
4-([[(1Z)-(2-chlorophenyl)methylidene]amino]methyl)benzenesulfonamide
Plasmodium falciparum
-
-
0.05
4-([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.000154
4-amino-N-(2-[4-[(aminooxy)sulfinyl]phenyl]ethyl)benzenesulfonamide
Saccharomyces cerevisiae
-
-
0.000166
4-amino-N-[4-[(aminooxy)sulfinyl]benzyl]benzenesulfonamide
Saccharomyces cerevisiae
-
-
0.000124
4-amino-N-[5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-yl]benzenesulfonamide
Saccharomyces cerevisiae
-
-
0.13 - 0.75
4-aminosalicylic acid
0.019
4-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)butan-1-one
Gallus gallus
-
pH 7.4, 37°C
0.05
4-sulfamoyl-N-(4-sulfamoylphenyl)benzamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.29 - 0.72
4-sulfosalicylic acid
0.000248
4-[(aminooxy)sulfinyl]-2-bromoaniline
Saccharomyces cerevisiae
-
-
0.000457
4-[(aminooxy)sulfinyl]-2-chloroaniline
Saccharomyces cerevisiae
-
-
0.000389
4-[(aminooxy)sulfinyl]-2-fluoroaniline
Saccharomyces cerevisiae
-
-
0.000976
4-[(aminooxy)sulfinyl]-2-iodoaniline
Saccharomyces cerevisiae
-
-
0.0185
4-[(aminooxy)sulfinyl]aniline
Saccharomyces cerevisiae
-
-
0.00754
4-[(aminooxy)sulfinyl]benzoic acid
Saccharomyces cerevisiae
-
-
0.05
4-[([(1Z)-[4-(dimethylamino)phenyl]methylidene]amino)methyl]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
4-[([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)methyl]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.008 - 0.068
4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide
0.0072 - 0.06
4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide
0.0075 - 0.084
4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide
0.0077 - 0.077
4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide
0.0069 - 0.39
4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide
0.007 - 0.061
4-[2-(2-thienyl)acetamido]benzenesulfonamide
0.05
4-[2-[(2-oxo-2H-chromen-3-yl)carbonyl]hydrazino]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
4-[2-[(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl]hydrazino]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
4-[3-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)propyl]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
4-[[(1Z)-(1-bromonaphthalen-2-yl)methylidene]amino]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
4-[[(3,4-dichlorophenyl)carbamoyl]amino]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
4-[[(diphenylcarbamoyl)amino]methyl]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.0061 - 0.063
5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide
0.00072 - 0.00407
5-chlorosalicylic acid
0.29 - 0.42
5-sulfosalicylic acid
0.000447
5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-amine
Saccharomyces cerevisiae
-
-
0.00036
5-[(aminooxy)sulfinyl]-3-methyl-1,3,4-thiadiazol-2(3H)-imine
Saccharomyces cerevisiae
-
-
0.0074 - 0.072
5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide
0.05
5-[[(pentafluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
5-[[(phenylcarbamoyl)carbamothioyl]amino]-1,3,4-thiadiazole-2-sulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.000019 - 1.145
acetazolamide
1.16 - 2.71
Acetylsalicylic acid
0.01 - 159
Ag+
0.0165
Atrazine
Apis mellifera
-
measured with hydration of CO2 activity assay, pH and temperature not specified in the publication
0.003 - 4.1
azide
0.556
benzyl 2-thioxobenzo[d]oxazol-3(2H)-carboxylate
Gallus gallus
-
pH 7.4, 37°C
0.1
bicarbonate
Leptonychotes weddellii
-
pH 7.5, 20°C, inhibition of CO2 hydration activity
1.01 - 69
bromide
0.00824
Caffeine
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
0.0462 - 0.3465
callistephin
0.0031 - 0.398
Carbaryl
0.0087
carbofuran
Apis mellifera
-
measured with hydration of CO2 activity assay, pH and temperature not specified in the publication
0.06
Carbonate
Leptonychotes weddellii
-
pH 7.5, 20°C, inhibition of CO2 hydration activity
82.5
Cd2+
Oncorhynchus mykiss
-
in 0.05 M Tris-SO4 buffer, at pH 9.0 and 25°C
240
Chlorate
Pseudomonas fragi
-
-
0.89 - 180
chloride
2.2
ClO4-
Dunaliella salina
IC50: 2.2 mM
0.03 - 3
Co2+
0.63 - 76.7
Cu2+
0.087 - 0.28
Cyanate
0.0008 - 0.31
cyanide
0.00038
dexamethasone
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
0.0027 - 0.00338
diflunisal
0.0028 - 0.00764
dinitrosalicylic acid
0.26
dithiothreitol
Halothiobacillus neapolitanus
-
-
1830 - 2090
ethanol
0.000001 - 0.044
ethoxyzolamide
0.78 - 1.22
Fe2+
0.74 - 350
fluoride
0.07
H2NSO2NH2
Leptonychotes weddellii
-
pH 7.5, 20°C, inhibition of CO2 hydration activity
0.055
H2NSO3H
Leptonychotes weddellii
-
pH 7.5, 20°C, inhibition of CO2 hydration activity
0.4
Hg2+
Ovis aries
-
pH 7.4, 25°C, purified enzyme
0.59
HSO3-
Leptonychotes weddellii
-
pH 7.5, 20°C, inhibition of CO2 hydration activity
100
I-
Dunaliella salina
IC50: 100 mM
0.15 - 29
Iodide
0.00276
ivermectin
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
1.151
KSCN
Bos taurus
-
at pH 7.0 and 20°C
0.1155 - 0.231
malvin
0.018
maneb
Acipenser gueldenstaedtii
-
pH 7.4, 30°C, inhibition of CO2 hydration activity
0.2855
metamizole sodium
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
0.021
methyl-3-(3-phenylpropanoyl)-2,3-dihydro-2-thioxobenzo[d]oxazole-5-carboxylate
Gallus gallus
-
pH 7.4, 37°C
0.00267
N'',N'''-Bis[(E)-(2,4-dichlorophenyl)methylidene]carbonic dihydrazide
Homo sapiens
pH 7.4, 25°C
0.00146
N'',N'''-bis[(E)-(2,6-dichlorophenyl)methylidene]carbonic dihydrazide
Homo sapiens
pH 7.4, 25°C
0.00396
N'',N'''-bis[(E)-(2-bromophenyl)methylidene]carbonic dihydrazide
Homo sapiens
pH 7.4, 25°C
0.00137
N'',N'''-bis[(E)-(2-chloro-5-nitrophenyl)methylidene]carbonic dihydrazide
Homo sapiens
pH 7.4, 25°C
0.00233
N'',N'''-bis[(E)-(2-chlorophenyl)methylidene]carbonic dihydrazide
Homo sapiens
pH 7.4, 25°C
0.00185
N'',N'''-bis[(E)-(2-nitrophenyl)methylidene]carbonic dihydrazide
Homo sapiens
pH 7.4, 25°C
0.00232
N'',N'''-bis[(E)-(4-bromophenyl)methylidene]carbonic dihydrazide
Homo sapiens
pH 7.4, 25°C
0.00133
N'',N'''-bis[(E)-(4-nitrophenyl)methylidene]carbonic dihydrazide
Homo sapiens
pH 7.4, 25°C
0.05
N-[(4-[[(4-sulfamoylphenyl)carbamothioyl]amino]phenyl)sulfonyl]acetamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
N-[2,4-disulfamoyl-5-(trifluoromethyl)phenyl]-2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
N-[2,4-disulfamoyl-5-(trifluoromethyl)phenyl]-2-oxo-2H-chromene-3-carboxamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
N-[4-[(aminooxy)sulfinyl]phenyl]-4-[(diphenylcarbamoyl)amino]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
0.05
N-[5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-yl]-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide
Plasmodium falciparum
-
IC50 above 0.05 mM
50
N3-
Dunaliella salina
IC50: about 50 mM
1.529
NaN3
Bos taurus
-
at pH 7.0 and 20°C
0.01 - 55.6
nitrate
0.9
nitrite
Leptonychotes weddellii
-
pH 7.5, 20°C, inhibition of CO2 hydration activity
0.00035 - 0.0187
oenin
0.0058
p-aminomethylbenzenesulfonamide
Dunaliella salina
IC50: 0.0058 mM
0.102
parathion
Acipenser gueldenstaedtii
-
pH 7.4, 30°C, inhibition of CO2 hydration activity
0.11 - 0.13
Pb2+
0.057
PhAsO3H2
Leptonychotes weddellii
-
pH 7.5, 20°C, inhibition of CO2 hydration activity
0.046
PhB(OH)2
Leptonychotes weddellii
-
pH 7.5, 20°C, inhibition of CO2 hydration activity
0.016
propineb
Acipenser gueldenstaedtii
-
pH 7.4, 30°C, inhibition of CO2 hydration activity
0.0321
propoxur
Apis mellifera
-
measured with hydration of CO2 activity assay, pH and temperature not specified in the publication
0.56 - 0.68
salicylic acid
0.0013 - 0.0433
silychristin
0.0273
simazine
Apis mellifera
-
measured with hydration of CO2 activity assay, pH and temperature not specified in the publication
0.0366
sulfamezathine
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
0.007 - 0.824
sulfanilamide
0.00304 - 0.00449
sulfasalazine
0.82 - 200
sulfate
1
Sulfide
Leptonychotes weddellii
-
pH 7.5, 20°C, inhibition of CO2 hydration activity
0.004
sulphanilamide
Acipenser gueldenstaedtii
-
pH 7.4, 30°C, inhibition of CO2 hydration activity
0.0276
tavilin 50
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
0.003
tebuconazole
Apis mellifera
-
measured with hydration of CO2 activity assay, pH and temperature not specified in the publication
0.1147
tetramisol
Ovis aries
-
pH 7.4, 25°C, versus 4-nitrophenylacetate as substrate
0.097 - 1.5
thiocyanate
0.01 - 0.25
topiramate
0.31 - 47.1
Zn2+
0.00186 - 6.033
zonisamide
0.000565
[4-[(aminooxy)sulfinyl]phenyl]methanol
Saccharomyces cerevisiae
-
-
0.000559 - 0.05
[Co(1-benzyl-2-methylimidazole)2Cl2]
0.05
[Hg(1-benzyl-2-methylimidazole)2Cl2]
Homo sapiens
above, pH 7.5, 22°C
0.0309 - 0.05
[Zn(1-benzyl-2-methylimidazole)2Cl2]
additional information
additional information
-