4.1.99.22: GTP 3',8-cyclase
This is an abbreviated version!
For detailed information about GTP 3',8-cyclase, go to the full flat file.
Word Map on EC 4.1.99.22
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4.1.99.22
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bicistronic
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s-adenosyl-l-methionine
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s-adenosylmethionine
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pyranopterin
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monophosphate
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molybdopterin
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barrel
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auxiliary
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pterin
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epr
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adomet
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mocs2a
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gephyrin
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embodying
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xanthine
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ansme
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hexamer
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butirosin
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monoclinic
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5'-deoxyadenosine
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thermus
- 4.1.99.22
-
bicistronic
- s-adenosyl-l-methionine
- s-adenosylmethionine
-
pyranopterin
- monophosphate
- molybdopterin
-
barrel
-
auxiliary
- pterin
- epr
- adomet
-
mocs2a
-
gephyrin
-
embodying
- xanthine
- ansme
-
hexamer
- butirosin
-
monoclinic
- 5'-deoxyadenosine
-
thermus
Reaction
Synonyms
AT2G31955, cnx2, CNX2/MOCS1A, EC 4.1.99.18, MoaA, MoaC, Moco-biosynthesis protein, MOCS1A, MOCS1B, MogA, molybdenum cofactor biosynthetic enzyme, molybdenum-cofactor biosynthesis protein
ECTree
4.1.99.22 GTP 3',8-cyclaseAdvanced search results
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results (Systematic Name
Systematic Name on EC 4.1.99.22 - GTP 3',8-cyclase
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SYSTEMATIC NAME 
IUBMB Comments
GTP 3',8-cyclase [(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate-forming]
The enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor (MoCo). In bacteria and plants the reaction is catalysed by MoaA and Cnx2, respectively. In mammals it is catalysed by the MOCS1A domain of the bifunctional MOCS1 protein, which also catalyses EC 4.6.1.17, cyclic pyranopterin monophosphate synthase. The enzyme belongs to the superfamily of radical S-adenosyl-L-methionine (radical SAM) enzymes, and contains two oxygen-sensitive FeS clusters.
