4.1.99.22: GTP 3',8-cyclase
This is an abbreviated version!
For detailed information about GTP 3',8-cyclase, go to the full flat file.
Word Map on EC 4.1.99.22
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4.1.99.22
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bicistronic
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s-adenosyl-l-methionine
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s-adenosylmethionine
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pyranopterin
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monophosphate
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molybdopterin
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barrel
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auxiliary
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pterin
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epr
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adomet
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mocs2a
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gephyrin
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embodying
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xanthine
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ansme
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hexamer
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butirosin
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monoclinic
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5'-deoxyadenosine
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thermus
- 4.1.99.22
-
bicistronic
- s-adenosyl-l-methionine
- s-adenosylmethionine
-
pyranopterin
- monophosphate
- molybdopterin
-
barrel
-
auxiliary
- pterin
- epr
- adomet
-
mocs2a
-
gephyrin
-
embodying
- xanthine
- ansme
-
hexamer
- butirosin
-
monoclinic
- 5'-deoxyadenosine
-
thermus
Reaction
Synonyms
AT2G31955, cnx2, CNX2/MOCS1A, EC 4.1.99.18, MoaA, MoaC, Moco-biosynthesis protein, MOCS1A, MOCS1B, MogA, molybdenum cofactor biosynthetic enzyme, molybdenum-cofactor biosynthesis protein
ECTree
4.1.99.22 GTP 3',8-cyclaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.1.99.22 - GTP 3',8-cyclase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate
cyclic pyranopterin phosphate + diphosphate
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reaction of MoaC
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-
?
GTP
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate
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reaction of MoaA with GTP, S-adenosyl-L-methionine, and sodium dithionite in the absence of MoaC
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-
?
GTP + S-adenosyl-L-methionine + reduced electron acceptor
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor
additional information
?
-
-
MoaA catalyzes a unique radical C-C bond formation reaction via a 5'-deoxyadenosyl radical intermediate and that, in contrast to previous proposals, MoaC plays a major role in the complex rearrangement to generate the pyranopterin ring
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-
?
GTP
cyclic pyranopterin phosphate + diphosphate
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MoaA cleaves GTP by a radical mechanism, a 5'-desoxyadenosyl radical is generated from S-adenosyl-L-methionine at the N-terminal cluster facilitating hydrogen abstraction at either the C8 of the guanine or the C2' or C3' atoms of the ribose. Insertion of the formyl group between the ribose C2' and C3' carbons might also require radical mediation. MoaC is involved in the cleavage of the dihydropyrazine-type intermediate pyrophosphate group and formation of the cPMP cyclic phosphate group
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-
?
GTP
cyclic pyranopterin phosphate + diphosphate
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the enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor
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-
?
GTP
cyclic pyranopterin phosphate + diphosphate
the enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor
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-
?
GTP + S-adenosyl-L-methionine + reduced electron acceptor
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor
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-
-
?
GTP + S-adenosyl-L-methionine + reduced electron acceptor
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor
-
-
-
?
GTP + S-adenosyl-L-methionine + reduced electron acceptor
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor
-
-
-
?
GTP + S-adenosyl-L-methionine + reduced electron acceptor
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor
-
-
-
?
