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4.1.99.22: GTP 3',8-cyclase

This is an abbreviated version!
For detailed information about GTP 3',8-cyclase, go to the full flat file.

Word Map on EC 4.1.99.22

Reaction

GTP
+
S-adenosyl-L-methionine
+
reduced electron acceptor
=
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate
+
5'-deoxyadenosine
+
L-methionine
+
oxidized electron acceptor

Synonyms

AT2G31955, cnx2, CNX2/MOCS1A, EC 4.1.99.18, MoaA, MoaC, Moco-biosynthesis protein, MOCS1A, MOCS1B, MogA, molybdenum cofactor biosynthetic enzyme, molybdenum-cofactor biosynthesis protein

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.99 Other carbon-carbon lyases
                4.1.99.22 GTP 3',8-cyclase

Engineering

Engineering on EC 4.1.99.22 - GTP 3',8-cyclase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C24S/C28S/C31S
-
the mutant does not contain the catalytic S-adenosyl-L-methionine-binding cluster I
D198A
mutation in GG motif, decrease in affinity for S-adenosine-L-methionine
G339A
mutation in GG motif, loss of activity
G340A
mutation in GG motif, loss of activity
N124A/N165A
mutation reduces binding of 5'-GTP
R17A
complete loss of activity
R17A/R266A/R268A
complete loss of activity
R192A
80% loss of activity
R266A
complete loss of activity
R268A
complete loss of activity
R71A
80% loss of activity
S126A
mutant enzyme with low activity
T73A
mutant enzyme with low activity
Y30A
mutant enzyme with low activity
D198A
-
mutation in GG motif, decrease in affinity for S-adenosine-L-methionine
-
G339A
-
mutation in GG motif, loss of activity
-
G340A
-
mutation in GG motif, loss of activity
-
additional information