4.1.99.19: 2-iminoacetate synthase
This is an abbreviated version!
For detailed information about 2-iminoacetate synthase, go to the full flat file.
Reaction
Synonyms
thiH
ECTree
4.1.99.19 2-iminoacetate synthaseAdvanced search results
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Reaction on EC 4.1.99.19 - 2-iminoacetate synthase
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REACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+
L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+
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L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+
ThiH is a member of the radical-S-adenosyl-L-methionine family. Proposed mechanism of ThiH-dependent cleavage of L-tyrosine: S-adenosyl-L-methionine is reductively cleaved to yield a highly reactive 5'-deoxyadenosyl radical. This radical is proposed to abstract the phenolic hydrogen atom from tyrosine, and the resultant substrate radical cleaves to yield dehydroglycine, which is required by ThiG for the thiazole cyclization reaction
