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4.1.99.19: 2-iminoacetate synthase

This is an abbreviated version!
For detailed information about 2-iminoacetate synthase, go to the full flat file.

Reaction

L-tyrosine
+
S-adenosyl-L-methionine
+
NADPH
=
2-iminoacetate
+
4-Methylphenol
+
5'-deoxyadenosine
+
L-methionine
+
NADP+
+
H+

Synonyms

thiH

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.99 Other carbon-carbon lyases
                4.1.99.19 2-iminoacetate synthase

Engineering

Engineering on EC 4.1.99.19 - 2-iminoacetate synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A26G
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
A272V
the thiH mutant allele results in a thiH null phenotype
A373P
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
A50T
the thiH mutant allele results in a thiH null phenotype
A51V
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
A61A
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
A61T
the thiH mutant allele results in a thiH null phenotype
C285A
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
C285H
the thiH mutant allele results in a thiH null phenotype
C89A
the thiH mutant allele results in a thiH null phenotype
D41V
the thiH mutant allele results in a thiH null phenotype
D6E
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
E131A
the thiH mutant allele results in a thiH null phenotype
E131K
the thiH mutant allele results in a thiH null phenotype
E187D
the thiH mutant allele results in a thiH null phenotype
E29K
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
E55G
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
E55K
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
G130A
the thiH mutant allele results in a thiH null phenotype
G216C
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
G22V
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
G327C
the thiH mutant allele results in a thiH null phenotype
h124Y
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
N87A
the thiH mutant allele results in a thiH null phenotype
N87K
the thiH mutant allele results in a thiH null phenotype
P334Q
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
P347S
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
Q338L
the thiH mutant allele results in a thiH null phenotype
R102P
the thiH mutant allele results in a thiH null phenotype
R205W
the thiH mutant allele results in a thiH null phenotype
T266N
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
V257A
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
V360I
the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole
W363C
the thiH mutant allele results in a thiH null phenotype
Y190C
the thiH mutant allele results in a thiH null phenotype
Y91A
the thiH mutant allele results in a thiH null phenotype