4.1.99.16: geosmin synthase
This is an abbreviated version!
For detailed information about geosmin synthase, go to the full flat file.
Word Map on EC 4.1.99.16
-
4.1.99.16
-
odor
-
geosmin-producing
-
taste
-
anabaena
-
cyanobacterial
-
isoprenoid
-
sesquiterpene
-
coelicolor
-
off-flavors
-
bloom
-
freshwater
-
amplicon
-
circinalis
-
2-methylisoborneol
-
terpenoid
-
terpene
-
trouble
-
dolichospermum
-
on-site
-
aquaculture
-
farnesyl
-
bornet
- 4.1.99.16
-
odor
-
geosmin-producing
-
taste
-
anabaena
-
cyanobacterial
-
isoprenoid
-
sesquiterpene
- coelicolor
-
off-flavors
-
bloom
-
freshwater
-
amplicon
- circinalis
- 2-methylisoborneol
-
terpenoid
-
terpene
-
trouble
-
dolichospermum
-
on-site
-
aquaculture
-
farnesyl
-
bornet
Reaction
Synonyms
Cyc2, geo, geoA, sce1440, ScGS, spterp13
ECTree
Advanced search results
Reaction
Reaction on EC 4.1.99.16 - geosmin synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone
conversion of germacradienol to geosmin results in the release of the three-carbon side chain as acetone and involves a 1,2-hydride shift of the bridgehead hydrogen exclusively into ring B of geosmin
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone
the active site in the N-terminal domain of enzyme ScGS catalyzes the ionization-dependent cyclization of FPP to form diphosphate and two cyclic products: germacradienol (major product, 85%) and germacrene D (minor product, 15%). After dissociation from the N-terminal domain, germacradienol is rebound to the active site of the C-terminal domain where it is converted to geosmin in a protonation-dependent cyclization reaction accompanied by the elimination of acetone through a retro-Prins reaction. The tandem cyclization-fragmentation reactions catalyzed by ScGS require two distinct active sites, a unique alphaalpha domain architecture is predicted for ScGS based on primary structure analysis
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone
the active site in the N-terminal domain of enzyme ScGS catalyzes the ionization-dependent cyclization of FPP to form diphosphate and two cyclic products: germacradienol (major product, 85%) and germacrene D (minor product, 15%). After dissociation from the N-terminal domain, germacradienol is rebound to the active site of the C-terminal domain where it is converted to geosmin in a protonation-dependent cyclization reaction accompanied by the elimination of acetone through a retro-Prins reaction. The tandem cyclization-fragmentation reactions catalyzed by ScGS require two distinct active sites, a unique alphaalpha domain architecture is predicted for ScGS based on primary structure analysis
Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145
-
-