4.1.99.14: spore photoproduct lyase

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For detailed information about spore photoproduct lyase, go to the full flat file.

Word Map on EC 4.1.99.14

4.1.99.14

photoproducts

thymine

5-thyminyl-5,6-dihydrothymine

s-adenosylmethionine

endospores

uv-irradiated

5\'-deoxyadenosyl

thymine-thymine

spla

5'-deoxyadenosine

h-atoms

beta-scission

photolyases

sp-containing

cxxxcxxc

deoxyadenosyl

thiyl

photolesion

forespore

radical-based

spore-specific

analysis

Reaction

(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double-helical DNA)

thymidylyl-(3'->5')-thymidylate (in double-helical DNA)

Synonyms

Bs SP lyase, Bs SPL, Ca SP lyase, Gt SP lyase, Gt SPL, GTNG_2348, More, SP lyase, SPL, SPL(Ca), spl-1, SplB, SplG, spore photoproduct lyase

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.99 Other carbon-carbon lyases

4.1.99.14 spore photoproduct lyase

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Results	in table
2	Activating Compound
920	AA Sequence
1	Application
17	Cloned(Commentary)
30	Cofactor
3	Crystallization (Commentary)
74	General Information
3	Inhibitors
7	KM Value [mM]
15	Metals/Ions
2	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
377	Organism
3	PDB ID
11	pH Optimum
1	pI Value
45	Protein Variants
15	Purification (Commentary)
26	Reaction
40	Reference
1	Renatured (Commentary)
3	Source Tissue
4	Specific Activity [micromol/min/mg]
65	Substrates and Products (Substrate)
7	Subunits
70	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 4.1.99.14 - spore photoproduct lyase

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spore photoproduct pyrimidine-lyase

This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme binds a [4Fe-4S] cluster. The cluster is coordinated by 3 cysteines and an exchangeable SAM molecule [3]. The 5'-deoxy-adenosine radical formed after electron transfer from the [4Fe-4S] cluster to the S-adenosyl-L-methionine, initiates the repair by abstracting the C-6 hydrogen of the spore photoproduct lesion. During the second part of the repair process the SAM molecule is regenerated [3].