4.1.99.14: spore photoproduct lyase
This is an abbreviated version!
For detailed information about spore photoproduct lyase, go to the full flat file.
Word Map on EC 4.1.99.14
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4.1.99.14
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photoproducts
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thymine
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5-thyminyl-5,6-dihydrothymine
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s-adenosylmethionine
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endospores
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uv-irradiated
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5\'-deoxyadenosyl
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thymine-thymine
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spla
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5'-deoxyadenosine
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h-atoms
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beta-scission
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photolyases
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sp-containing
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cxxxcxxc
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deoxyadenosyl
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thiyl
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photolesion
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forespore
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radical-based
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spore-specific
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analysis
- 4.1.99.14
- photoproducts
- thymine
- 5-thyminyl-5,6-dihydrothymine
- s-adenosylmethionine
- endospores
-
uv-irradiated
-
5\'-deoxyadenosyl
-
thymine-thymine
- spla
- 5'-deoxyadenosine
-
h-atoms
-
beta-scission
-
photolyases
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sp-containing
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cxxxcxxc
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deoxyadenosyl
-
thiyl
-
photolesion
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forespore
-
radical-based
-
spore-specific
- analysis
Reaction
Synonyms
Bs SP lyase, Bs SPL, Ca SP lyase, Gt SP lyase, Gt SPL, GTNG_2348, More, SP lyase, SPL, SPL(Ca), spl-1, SplB, SplG, spore photoproduct lyase
ECTree
4.1.99.14 spore photoproduct lyaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.1.99.14 - spore photoproduct lyase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(5''R)-alpha-5''(6''H)-bithymine + S-adenosyl-L-methionine
thymidylyl-(3'-5')-thymidylate + 5'-deoxyadenosine + L-methionine
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SPL repairs specifically the 5R isomer. (5''R)-alpha-5''(6''H)-bithymine is the diastereomer produced upon UV irradiation of a TpT dinucleotide
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-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'-5')-thymidylate
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the enzyme establishes a complex radical transfer cascade and creates a cysteine and a tyrosyl radical dyade to establish repair. This allows the enzyme to solve topological and energetic problems associated with the radical based repair reaction
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double helical DNA) + S-adenosyl-L-methionine + 2 H+
thymidylyl-(3'-5')-thymidylate (in DNA) + 5'-deoxyadenosine + L-methionine
5,6-dihydro-5-(thymidin-7-yl)thymidine (in double helical DNA)
thymidylyl-(3'-5')-thymidylate (in DNA)
-
-
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
-
-
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
-
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
-
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
-
-
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
-
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
Clostridium acetobutylicum ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine
thymidylyl-(3'->5')-thymidylate
in double-helical DNA
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double helical DNA) + S-adenosyl-L-methionine + 2 H+
thymidylyl-(3'-5')-thymidylate (in DNA) + 5'-deoxyadenosine + L-methionine
-
-
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double helical DNA) + S-adenosyl-L-methionine + 2 H+
thymidylyl-(3'-5')-thymidylate (in DNA) + 5'-deoxyadenosine + L-methionine
-
-
-
-
?
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double helical DNA) + S-adenosyl-L-methionine + 2 H+
thymidylyl-(3'-5')-thymidylate (in DNA) + 5'-deoxyadenosine + L-methionine
-
-
-
-
?
additional information
?
-
-
the (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine lesion does not absolutely need to be contained within a single or double-stranded DNA for recognition and repaired by the enzyme
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-
?
additional information
?
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DNA conformation during in vivo repair and dinucleotide SP TpT flipping process, overview
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-
?
additional information
?
-
DNA conformation during in vivo repair and dinucleotide SP TpT flipping process, overview
-
-
?
additional information
?
-
DNA conformation during in vivo repair and dinucleotide SP TpT flipping process, overview
-
-
?
additional information
?
-
DNA conformation during in vivo repair and dinucleotide SP TpT flipping process, overview
-
-
?
