4.1.99.13: (6-4)DNA photolyase
This is an abbreviated version!
For detailed information about (6-4)DNA photolyase, go to the full flat file.
Word Map on EC 4.1.99.13
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4.1.99.13
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photoproducts
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cyclobutane
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uv-induced
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cryptochromes
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photoreactivation
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light-dependent
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pyrimidone
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blue-light
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photorepair
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oxetane
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pyrimidine-pyrimidone
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photoreduction
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photolesion
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dash
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ostreococcus
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four-membered
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fadox
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photoreception
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cry-dashs
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dewar
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cryptochrome-dash
- 4.1.99.13
- photoproducts
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cyclobutane
-
uv-induced
-
cryptochromes
-
photoreactivation
-
light-dependent
-
pyrimidone
-
blue-light
-
photorepair
-
oxetane
-
pyrimidine-pyrimidone
-
photoreduction
-
photolesion
-
dash
- ostreococcus
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four-membered
- fadox
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photoreception
- cry-dashs
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dewar
- cryptochrome-dash
Reaction
Synonyms
(6-4) DNA photolyase, (6-4) photolyase, (6-4) PHR, (6-4) PL, (6-4) PP-specific PL, (6-4)-Phr, (6-4)photolyase, 6-4 DNA photolyase, 6-4 photolyase, 6-4CiPhr, 6-4PP-photolyase, animal (6-4) photolyase, At64, At64PHR, bacterial (6-4) photolyase, CmPHR1, Cry1, CryB, deoxyribodipyrimidine photolyase-related protein, Dm64, DNA photolyase, Ds64PHR, H64PRH, human (6-4) photolyase homologous protein, NF-10, OtCPF1, phr (6-4), PhrB, PL-(6-4), prokaryotic (6-4) photolyase, RSP_3077, TRIREDRAFT_77473, XELAEV_18035355mg, Xl64phr
ECTree
4.1.99.13 (6-4)DNA photolyaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.1.99.13 - (6-4)DNA photolyase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cyclobutadipyrimidine in DNA
2 pyrimidine residues in DNA
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
Agrobacterium fabrum C58 / ATCC 33970
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-
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
PhrB is active with ssDNA and dsDNA TT (6-4) photoproducts
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-
?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
Agrobacterium tumefaciens C58 / ATCC 33970
PhrB is active with ssDNA and dsDNA TT (6-4) photoproducts
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
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-
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
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-
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
Cereibacter sphaeroides ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
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-
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
(6-4) photolyases repair (6-4) pyrimidine-pyrimidone photoproducts. CmPHR1 exhibits a repair activity of both (6-4)-ssDNA and (6-4)-dsDNA. Cryptochromes CmPHR2 and CmPHR5 show CPD repair activity only on ssDNA, and have no repair activity when CPD-damaged dsDNA is used as a substrate
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
(6-4) photolyases repair (6-4) pyrimidine-pyrimidone photoproducts. CmPHR1 exhibits a repair activity of both (6-4)-ssDNA and (6-4)-dsDNA. Cryptochromes CmPHR2 and CmPHR5 show CPD repair activity only on ssDNA, and have no repair activity when CPD-damaged dsDNA is used as a substrate
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
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-
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
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-
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
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-
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?
(6-4) photoproduct (in DNA)
2 pyrimidine residues (in DNA)
Xiphophorus maculatus Jp 163 B
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?
additional information
?
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the repair function requires to transfer a functional group (OH in the case T(6-4)T) from the 5' to the 3' base, in addition to intradimer bond cleavage
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?
additional information
?
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the repair function requires to transfer a functional group (OH in the case T(6-4)T) from the 5' to the 3' base, in addition to intradimer bond cleavage
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?
additional information
?
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the repair function requires to transfer a functional group (OH in the case T(6-4)T) from the 5' to the 3' base, in addition to intradimer bond cleavage
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?
additional information
?
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cyclobutane pyrimidine dimer-photolyase (EC 4.1.99.3) or 6-4PP-photolyase are able to prevent UV-induced apoptosis in cells deficient for nucleotide excision repair to a similar extent, while in nucleotide excision repair-proficient cells UV-induced apoptosis is prevented only by cyclobutane pyrimidine dimer-photolyase, with no effects observed when pyrimidine-(6-4)-pyrimidone photoproducts are removed by the specific photolyase. Both cyclobutane pyrimidine dimers and pyrimidine-(6-4)-pyrimidone photoproducts contribute to UV-induced apoptosis in nucleotide excision repair-deficient cells, while in nucleotide excision repair-proficient cells, cyclobutane pyrimidine dimers are the only lesions responsible for UV-killing, probably due to the rapid repair of pyrimidine-(6-4)-pyrimidone photoproducts by nucleotide excision repair
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?
