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4.1.3.46: (R)-citramalyl-CoA lyase

This is an abbreviated version!
For detailed information about (R)-citramalyl-CoA lyase, go to the full flat file.

Reaction

(3R)-citramalyl-CoA
=
acetyl-CoA
 +
pyruvate

Synonyms

CCL, CclA, citramalyl-CoA lyase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.46 (R)-citramalyl-CoA lyase

Metals Ions

Metals Ions on EC 4.1.3.46 - (R)-citramalyl-CoA lyase

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
enzyme activity is stimulated by divalent cations in the order Mn2+, Co2+ > Ni2+ > Mg2+
copper
-
the recombinant enzyme contains 0.5 mol of zinc per mol of native enzyme. Additionally, 0.2 mol copper per mol native protein and traces of iron are detected
Mn2+
-
enzyme activity is stimulated by divalent cations in the order Mn2+, Co2+ > Ni2+ > Mg2+. The addition of both 4 mM dithioerythritol and 4 mM Mn2+ enhances the enzyme activity approximately 10fold compared to the results of an assay lacking dithioerythritol and Mn2+
Ni2+
-
enzyme activity is stimulated by divalent cations in the order Mn2+, Co2+ > Ni2+ > Mg2+
Zinc
-
the recombinant enzyme contains 0.5 mol of zinc per mol of native enzyme. Additionally, 0.2 mol copper per mol native protein and traces of iron are detected
additional information
-
no stimulation is obtained after the addition of Ca2+