4.1.3.39: 4-hydroxy-2-oxovalerate aldolase

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For detailed information about 4-hydroxy-2-oxovalerate aldolase, go to the full flat file.

Word Map on EC 4.1.3.39

4.1.3.39

hydratase

meta-cleavage

catechols

4-oxalocrotonate

2-hydroxymuconic

2,3-dioxygenase

2-hydroxypenta-2,4-dienoate

putida

biphenyls

semialdehyde

dioxygenase

extradiol

enol

tautomerase

polychlorinated

ethylbenzene

meta-pathway

isofunctional

stearothermophilus

xylf

propionaldehyde

aldolases

Reaction

Synonyms

4-hydroxy-2-ketovalerate aldolase, 4-hydroxy-2-ketovalerate aldolase-aldehyde dehydrogenase (acylation), BphI, class II pyruvate aldolase BphI, DmpFG, HOA, HsaF, MhpE, pyruvate aldolase

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.3 Oxo-acid-lyases

4.1.3.39 4-hydroxy-2-oxovalerate aldolase

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Results	in table
4	Activating Compound
7344	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
1	Cofactor
3	Crystallization (Commentary)
3	General Information
16	Inhibitors
50	kcat/KM [mM/s]
15	Ki Value [mM]
36	KM Value [mM]
10	Metals/Ions
7	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
38	Organism
13	Pathway
5	PDB ID
3	pH Optimum
2	pH Range
9	Protein Variants
5	Purification (Commentary)
7	Reaction
17	Reference
2	Specific Activity [micromol/min/mg]
2	Storage Stability
69	Substrates and Products (Substrate)
14	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
36	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.1.3.39 - 4-hydroxy-2-oxovalerate aldolase

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4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)

Requires Mn2+ for maximal activity [1]. The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH [1]. In some bacterial species the enzyme forms a bifunctional complex with EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase [4,5].