Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.1.3.39: 4-hydroxy-2-oxovalerate aldolase

This is an abbreviated version!
For detailed information about 4-hydroxy-2-oxovalerate aldolase, go to the full flat file.

Word Map on EC 4.1.3.39

Reaction

(S)-4-hydroxy-2-oxopentanoate
=
acetaldehyde
+
pyruvate

Synonyms

4-hydroxy-2-ketovalerate aldolase, 4-hydroxy-2-ketovalerate aldolase-aldehyde dehydrogenase (acylation), BphI, class II pyruvate aldolase BphI, DmpFG, HOA, HsaF, MhpE, pyruvate aldolase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.39 4-hydroxy-2-oxovalerate aldolase

Engineering

Engineering on EC 4.1.3.39 - 4-hydroxy-2-oxovalerate aldolase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H20A
-
decrease in kcat/Km value
H20S
-
decrease in kcat/Km value
L87A
-
3-fold reduction in kcat/Km
L87A/L89A
-
improved specificity for aldehydes at least four carbons in length
L89A
-
kcat/Km similar to wild type
R16A
-
no detectable activity
R16K
-
increased Km value for 4-hydroxy-2-oxopentanoate
Y290F
-
lower kcat value
Y290S
-
lower kcat value