4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase
This is an abbreviated version!
For detailed information about 1,4-dihydroxy-2-naphthoyl-CoA synthase, go to the full flat file.
Word Map on EC 4.1.3.36
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4.1.3.36
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menaquinone
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tuberculosis
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crotonase
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1,4-dihydroxy-2-naphthoic
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hexamer
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o-succinylbenzoyl-coa
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o-succinylbenzoic
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oxyanion
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induced-fit
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claisen
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reorientation
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tetrahedral
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osb-coa
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phlei
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5'-triphosphate
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trimer-trimer
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enzyme-ligand
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medicine
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drug development
- 4.1.3.36
- menaquinone
- tuberculosis
- crotonase
-
1,4-dihydroxy-2-naphthoic
-
hexamer
- o-succinylbenzoyl-coa
-
o-succinylbenzoic
-
oxyanion
-
induced-fit
-
claisen
-
reorientation
-
tetrahedral
-
osb-coa
- phlei
- 5'-triphosphate
-
trimer-trimer
-
enzyme-ligand
- medicine
- drug development
Reaction
Synonyms
1,4-dihydroxy-2-naphthoate synthetase, 1,4-dihydroxy-2-naphthoyl coenzyme A synthase, 1,4-dihydroxy-2-naphthoyl-CoA synthase, 1,4-dihydroxy-2-naphthoyl-coenzyme synthase, DHNA synthetase, DHNA-CoA synthase, dihydroxynaphthoate synthase, Dihydroxynaphthoic acid synthetase, MenB, naphthoate synthase, naphthoate synthase (MenB), Rv0548c, synthase, 1,4-dihydroxy-2-naphthoate
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 4.1.3.36 - 1,4-dihydroxy-2-naphthoyl-CoA synthase
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REACTION DIAGRAM
o-succinylbenzoate + CoA
1,4-dihydroxy-2-naphthoyl-CoA + H2O
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formation of a structural motif like an oxyanion hole for orientation of the o-succinylbenzoate substrate and stabilization of the oxyanion intermediate in the intramolecular Claisen condensation, which involves a conserved tyrosine residue in the A-loop. via induced fit
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-
?
o-succinylbenzoate + CoA
1,4-dihydroxy-2-naphthoyl-CoA + H2O
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-
-
?
o-succinylbenzoate + CoA
1,4-dihydroxy-2-naphthoyl-CoA + H2O
formation of a structural motif like an oxyanion hole for orientation of the o-succinylbenzoate substrate and stabilization of the oxyanion intermediate in the intramolecular Claisen condensation, which involves a conserved tyrosine residue in the A-loop via induced fit
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-
?
1,4-dihydroxy-2-naphthoyl-CoA + H2O
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-
-
-
?
o-succinylbenzoyl-CoA
1,4-dihydroxy-2-naphthoyl-CoA + H2O
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-
-
?
o-succinylbenzoyl-CoA
1,4-dihydroxy-2-naphthoyl-CoA + H2O
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-
-
?
?
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pathway in menaquinone biosynthesis, i.e. vitamin K2, cf. EC 6.2.1.26
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-
?
o-succinylbenzoyl-CoA
?
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pathway in menaquinone biosynthesis, i.e. vitamin K2, cf. EC 6.2.1.26
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-
?
o-succinylbenzoyl-CoA
?
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pathway in menaquinone biosynthesis, i.e. vitamin K2, cf. EC 6.2.1.26
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-
?