4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase

This is an abbreviated version!
For detailed information about 1,4-dihydroxy-2-naphthoyl-CoA synthase, go to the full flat file.

Reaction

Synonyms

1,4-dihydroxy-2-naphthoate synthetase, 1,4-dihydroxy-2-naphthoyl coenzyme A synthase, 1,4-dihydroxy-2-naphthoyl-CoA synthase, 1,4-dihydroxy-2-naphthoyl-coenzyme synthase, DHNA synthetase, DHNA-CoA synthase, dihydroxynaphthoate synthase, Dihydroxynaphthoic acid synthetase, MenB, naphthoate synthase, naphthoate synthase (MenB), Rv0548c, synthase, 1,4-dihydroxy-2-naphthoate

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.36 1,4-dihydroxy-2-naphthoyl-CoA synthase

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Results	in table
14675	AA Sequence
3	Application
1	CAS Registry Number
13	Cloned(Commentary)
3	Cofactor
10	Crystallization (Commentary)
9	General Information
2	General Stability
29	IC50 Value
57	Inhibitors
10	kcat/KM [mM/s]
10	Ki Value [mM]
10	KM Value [mM]
1	Localization
4	Metals/Ions
3	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
28	Organism
6	Pathway
142	PDB ID
5	pH Optimum
20	Protein Variants
18	Purification (Commentary)
5	Reaction
6	Reaction Type
26	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
33	Substrates and Products (Substrate)
7	Subunits
42	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
10	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 4.1.3.36 - 1,4-dihydroxy-2-naphthoyl-CoA synthase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000106

2-CoA-4-(2,4-dichlorophenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.000135

2-CoA-4-(2-bromophenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.000103

2-CoA-4-(2-chlorophenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.000204

2-CoA-4-(2-fluorophenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.000421

2-CoA-4-(2-iodophenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.0121

2-CoA-4-(2-methoxyphenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.000154

2-CoA-4-(2-nitrophenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.0141

2-CoA-4-(3-chlorophenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.00047

2-CoA-4-(4-dichlorophenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.0335

2-CoA-4-(4-methoxyphenyl)-4-oxobutanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.4

3-(2,4-dichlorophenyl)-3-oxopropyl-CoA

Mycobacterium tuberculosis

P9WNP5

above, pH 7.4, 25°C

726554

0.0022

4-(2,4-dichlorophenyl)-4-oxobutanoyl-CoA

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.0084

4-(2-chlorophenyl)-4-oxo-2-[[(1S)-1-phenylethyl]amino]butanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.12

4-(2-methoxyphenyl)-4-oxo-2-[[(1S)-1-phenylethyl]amino]butanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

117

4-(4-chlorophenyl)-4-oxo-2-[[(1S)-1-phenylethyl]amino]butanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.0144

4-(4-fluorophenyl)-4-oxo-2-[[(1S)-1-phenylethyl]amino]butanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.0032

4-oxo-2-[[(1S)-1-phenylethyl]amino]-4-[2-(trifluoromethyl)phenyl]butanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.0527

4-oxo-4-phenyl-2-[[(1S)-1-phenylethyl]amino]butanoic acid

Mycobacterium tuberculosis

P9WNP5

pH 7.4, 25°C

726554

0.01

methyl (2Z)-(2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

non-competitive inhibitor Ki' = 0.067 mM, pH not specified in the publication, temperature not specified in the publication

714417

0.0241

methyl (2Z)-(5-methyl-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

pH not specified in the publication, temperature not specified in the publication

714417

0.0463

methyl (2Z)-(6-chloro-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

non-competitive inhibitor Ki' = 0.0185 mM, pH not specified in the publication, temperature not specified in the publication

714417

0.027

methyl (2Z)-(6-fluoro-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

non-competitive inhibitor Ki' = 0.0101 mM, pH not specified in the publication, temperature not specified in the publication

714417

0.0231

methyl (2Z)-(6-methyl-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

pH not specified in the publication, temperature not specified in the publication

714417

0.0282

methyl (2Z)-(6-nitro-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

pH not specified in the publication, temperature not specified in the publication

714417

0.0357

methyl (2Z)-(7-chloro-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

pH not specified in the publication, temperature not specified in the publication

714417

0.03

methyl (2Z)-(7-fluoro-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

pH not specified in the publication, temperature not specified in the publication

714417

0.0182

methyl (2Z)-(7-methyl-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

pH not specified in the publication, temperature not specified in the publication

714417

0.0203

methyl (2Z)-(7-nitro-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene)ethanoate

Mycobacterium tuberculosis

-

pH not specified in the publication, temperature not specified in the publication

714417

0.0179

methyl (2Z)-[6-(ethylsulfonyl)-2-oxo-2H-1,4-benzoxazin-3(4H)-ylidene]ethanoate

Mycobacterium tuberculosis

-

pH not specified in the publication, temperature not specified in the publication

714417