4.1.3.32: 2,3-Dimethylmalate lyase

This is an abbreviated version!
For detailed information about 2,3-Dimethylmalate lyase, go to the full flat file.

Reaction

Synonyms

(2R,3S)-dimethylmalate lyase, 2,3-dimethylmalate lyase, An07g08390, DMML, Lyase, 2,3-dimethylmalate

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.32 2,3-Dimethylmalate lyase

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Results	in table
2	Activating Compound
376	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
3	Crystallization (Commentary)
1	General Information
14	Inhibitors
13	kcat/KM [mM/s]
16	Ki Value [mM]
54	KM Value [mM]
12	Metals/Ions
12	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
8	Organism
3	Pathway
28	PDB ID
3	pH Optimum
1	pH Range
20	Protein Variants
4	Purification (Commentary)
2	Reaction
8	Reference
35	Substrates and Products (Substrate)
6	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
69	Turnover Number [1/s]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 4.1.3.32 - 2,3-Dimethylmalate lyase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(2R)-ethyl-(3S)-methylmalate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(2R)-ethylmalate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(2R)-methylmalate

?

2 entries

(2R)-propyl-(3S)-methylmalate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(2R,3S)-2,3-dimethylmalate

propanoate + pyruvate

3 entries

(2R,3S)-2-methylisocitrate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(2R,3S)-dimethylmalate

propanoate + pyruvate

2 entries

(2R,3S)-isocitrate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(2R,3S)-methylisocitrate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(2S)-methylmalate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(2S,3R)-2-methylisocitrate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(3S)-isopropylmalate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(R)-malate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(S)-malate

?

2 entries

2,3-Dimethylmalate

Propanoate + pyruvate

4 entries

3,3-difluorooxaloacetate

?

Aspergillus niger

-

-

748428

-

-

?

3,3-difluoroxaloacetate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

3-butylmalate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

carboxyphosphoenolpyruvate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

oxaloacetate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

oxaloacetate

acetate + oxalate

Aspergillus niger

Q2L887

-

693684

-

-

?

oxaloacetate

oxalate + acetate

Aspergillus niger

-

-

748428

-

-

?

phosphonopyruvate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

additional information

?

-

7 entries

(2R)-methylmalate

?

Aspergillus niger

-

-

748428

-

-

?

(2R)-methylmalate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

(2R,3S)-2,3-dimethylmalate

propanoate + pyruvate

Aspergillus niger

-

-

748428

-

-

?

(2R,3S)-2,3-dimethylmalate

propanoate + pyruvate

Aspergillus niger

Q2L887

-

693684

-

-

?

(2R,3S)-2,3-dimethylmalate

propanoate + pyruvate

Mycobacterium tuberculosis

-

-

748460

-

-

?

(2R,3S)-dimethylmalate

propanoate + pyruvate

Aspergillus niger

Q2L887

-

693684

-

-

?

(2R,3S)-dimethylmalate

propanoate + pyruvate

Eubacterium barkeri

-

-

670692

-

-

?

(S)-malate

?

Aspergillus niger

-

-

748428

-

-

?

(S)-malate

?

Aspergillus niger

Q2L887

-

693684

-

-

?

2,3-Dimethylmalate

Propanoate + pyruvate

Eubacterium barkeri

-

-

5349

-

5349

?

2,3-Dimethylmalate

Propanoate + pyruvate

Eubacterium barkeri

-

-

5352

-

5352

?

2,3-Dimethylmalate

Propanoate + pyruvate

Eubacterium barkeri

-

(2R,3S)-2,3-dimethylmalate

5350

-

5350

?

2,3-Dimethylmalate

Propanoate + pyruvate

Eubacterium barkeri

-

(2R,3S)-2,3-dimethylmalate

5351

-

5351

?

additional information

?

-

Aspergillus niger

Q2L887

(2R,3S)-isocitrate, (R)-malate, (S)-malate, (2S)-methylmalate, (3S)-isopropylmalate, 3-butylmalate, phosphonopyruvate, carboxyphenolpyruvate, 3,3-difluoroxaloacetate, oxalate are no substrates

693684

-

-

?

additional information

?

-

Aspergillus niger

-

(2R,3S)-isocitrate, (R)-malate, (S)-malate, (2S)-methylmalate, (3S)-isopropylmalate, 3-butylmalate, phosphonopyruvate, carboxyphenolpyruvate, 3,3-difluoroxaloacetate, oxalate are no substrates

693684

-

-

?

additional information

?

-

Aspergillus niger

Q2L887

(2R,3S)-isocitrate, (R)-malate, (S)-malated, (2S)-methylmalate, (3S)-isopropylmalate, 3-butylmalate, phosphonopyruvate, carboxyphosphoenolpyruvate, 3,3-difluoroxaloacetate, and oxalate are no substrates

693684

-

-

?

additional information

?

-

Aspergillus niger

-

(2R,3S)-isocitrate, (R)-malate, (S)-malated, (2S)-methylmalate, (3S)-isopropylmalate, 3-butylmalate, phosphonopyruvate, carboxyphosphoenolpyruvate, 3,3-difluoroxaloacetate, and oxalate are no substrates

693684

-

-

?

additional information

?

-

Aspergillus niger

Q2L887

DMML also possesses significant oxaloacetate acetyl hydrolase activity

693684

-

-

?

additional information

?

-

Aspergillus niger

-

DMML also possesses significant oxaloacetate acetyl hydrolase activity

693684

-

-

?

additional information

?

-

Eubacterium barkeri

-

inducible enzyme

5352

-

-

?