4.1.3.25: (S)-citramalyl-CoA lyase
This is an abbreviated version!
For detailed information about (S)-citramalyl-CoA lyase, go to the full flat file.
Word Map on EC 4.1.3.25
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4.1.3.25
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itaconate
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hydratase
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succinate
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citramalate
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aeruginosa
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terreus
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yersinia
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succinyl-coa
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c5-dicarboxylic
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pestis
- 4.1.3.25
- itaconate
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hydratase
- succinate
- citramalate
- aeruginosa
- terreus
- yersinia
- succinyl-coa
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c5-dicarboxylic
- pestis
Reaction
Synonyms
(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase, (3S)-citramalyl-CoA pyruvate-lyase, (S)-citramalyl-CoA lyase, CCL, CclA, CitE-like protein, citramalyl coenzyme A lyase, citramalyl-CoA lyase, citramalyl-thio-acyl carrier protein lyase, D-citramalyl-CoA lyase, lyase, citramalyl coenzyme A, malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase, MCL, MCLC, More, YpCcl
ECTree
4.1.3.25 (S)-citramalyl-CoA lyaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.1.3.25 - (S)-citramalyl-CoA lyase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-citramalyl-CoA
acetyl-CoA + pyruvate
the cleavage direction is preferred
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r
acetyl-CoA + pyruvate
(3S)-citramalyl-CoA
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i.e. (-)citramalyl-CoA
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additional information
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the enzyme also performs reactions of EC 4.1.3.24, catalyzing reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate, or reversible synthesis of (2R,3S)-2-methylmalyl-CoA from propanoyl-CoA and glyoxylate. Malyl-CoA lyase is a promiscuous carbon-carbon bond lyase that catalyzes the reversible cleavage of structurally related CoA thioesters
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?
additional information
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the enzyme also performs reactions of EC 4.1.3.24, catalyzing reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate, or reversible synthesis of (2R,3S)-2-methylmalyl-CoA from propanoyl-CoA and glyoxylate
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?
additional information
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PaCcl is highly specific for its substrate, (S)-citramalyl-CoA. It also catalyzes stereospecifically the (R)-3-hydroxy-3-methylglutaryl-CoA lyase reaction and the (3S)-citryl-CoA lyase reaction, EC 4.1.3.34, albeit with much lower catalytic efficiency. No activity with (S)-3-hydroxy-3-methylglutaryl-CoA
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additional information
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PaCcl is highly specific for its substrate, (S)-citramalyl-CoA. It also catalyzes stereospecifically the (R)-3-hydroxy-3-methylglutaryl-CoA lyase reaction and the (3S)-citryl-CoA lyase reaction, EC 4.1.3.34, albeit with much lower catalytic efficiency. No activity with (S)-3-hydroxy-3-methylglutaryl-CoA
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?
additional information
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involved in the pathway for degradation of 3,5-xylenol
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?
additional information
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involved in the pathway for degradation of 3,5-xylenol
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?
additional information
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YpCcl does not accept other tested beta-hydroxyacyl-CoA compounds, such as 3-hydroxy-3-methylglutaryl-CoA, (3S)-malyl-CoA or beta-methylmalyl-CoA as substrates, but it catalyzes the (3S)-citryl-CoA lyase reaction, EC 4.1.3.34, albeit with lower catalytic efficiency
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?
additional information
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YpCcl does not accept other tested beta-hydroxyacyl-CoA compounds, such as 3-hydroxy-3-methylglutaryl-CoA, (3S)-malyl-CoA or beta-methylmalyl-CoA as substrates, but it catalyzes the (3S)-citryl-CoA lyase reaction, EC 4.1.3.34, albeit with lower catalytic efficiency
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