4.1.3.24: malyl-CoA lyase
This is an abbreviated version!
For detailed information about malyl-CoA lyase, go to the full flat file.
Word Map on EC 4.1.3.24
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4.1.3.24
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malate
-
methylobacterium
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extorquens
-
facultative
-
3-hydroxypropionate
-
methanol
-
carboxylase
-
propionyl-coa
-
sphaeroides
-
chloroflexus
-
phosphoenolpyruvate
-
rhodobacter
-
phototrophic
-
aurantiacus
-
ethylmalonyl-coa
-
hydroxypyruvate
-
one-carbon
-
thioesters
-
acetyl-coenzyme
-
ribulose
-
succinyl-coa
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lyases
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carbon-carbon
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roseiflexus
-
succinate-grown
-
multicarbon
-
3-hydroxybutyrate
-
calvin
-
condenses
- 4.1.3.24
- malate
-
methylobacterium
- extorquens
-
facultative
- 3-hydroxypropionate
- methanol
- carboxylase
- propionyl-coa
- sphaeroides
-
chloroflexus
- phosphoenolpyruvate
-
rhodobacter
-
phototrophic
- aurantiacus
- ethylmalonyl-coa
- hydroxypyruvate
-
one-carbon
- thioesters
-
acetyl-coenzyme
- ribulose
- succinyl-coa
- lyases
-
carbon-carbon
-
roseiflexus
-
succinate-grown
-
multicarbon
- 3-hydroxybutyrate
-
calvin
-
condenses
Reaction
Synonyms
(3S)-malyl-CoA lyase, (3S)-malyl-coenzyme A lyase, L-malyl-CoA lyase/beta-methylmalyl-CoA lyase, L-malyl-CoA/beta-methylmalyl-CoA lyase, L-malyl-coenzyme A/beta-methylmalyl-coenzyme A lyase, lyase, malyl coenzyme A, malyl coenzyme A lyase, malyl-CoA lyase, malyl-CoA/beta-methylmalyl-CoA lyase, malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase, MCL, Mcl1, MCLC, MCLR
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Substrates Products
Substrates Products on EC 4.1.3.24 - malyl-CoA lyase
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REACTION DIAGRAM
propionyl-CoA + glyoxylate
(2S)-4-(beta-methyl)-malyl-CoA
-
-
-
r
(2R,3S)-2-methylmalyl-CoA
propanoyl-CoA + glyoxylate
the synthesis direction is preferred
-
-
r
(2R,3S)-2-methylmalyl-CoA
propanoyl-CoA + glyoxylate
the synthesis direction is preferred
-
-
r
(2R,3S)-2-methylmalyl-CoA
propanoyl-CoA + glyoxylate
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
r
(2R,3S)-2-methylmalyl-CoA
propanoyl-CoA + glyoxylate
Chloroflexus aurantiacus OK-70-fl / DSM 636
the synthesis direction is preferred
-
-
r
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
r
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
malyl-CoA
-
r
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
enzyme in 3-hydroxypropionate cycle
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
Chloroflexus aurantiacus OK-70-fl / DSM 636
-
enzyme in 3-hydroxypropionate cycle
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
Methylobacterium hypolimneticum
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
Methylobacterium methanolicum
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
r
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
r
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
Pseudomonas methanolica
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
acetyl-CoA + glyoxylate
-
-
-
?
(S)-malyl-CoA
acetyl-CoA + glyoxylate
the cleavage direction is preferred
-
-
r
(S)-malyl-CoA
acetyl-CoA + glyoxylate
the cleavage direction is preferred
-
-
r
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
-
-
-
r
acetyl-CoA + glyoxylate
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
-
-
-
r
beta-methylmalyl-CoA
glyoxylate + propionyl-CoA
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
-
-
-
-
?
erythro-beta-methylmalyl-CoA
-
-
-
?
?
-
malyl-CoA lyase is a promiscuous carbon-carbon bond lyase that catalyzes the reversible cleavage of structurally related CoA thioesters
-
-
?
additional information
?
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-
malyl-CoA lyase is a promiscuous carbon-carbon bond lyase that catalyzes the reversible cleavage of structurally related CoA thioesters
-
-
?
additional information
?
-
modeling of binding structures of glyoxylate, acetyl-CoA, pyruvate, and Mg2+, overview
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-
?
additional information
?
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-
modeling of binding structures of glyoxylate, acetyl-CoA, pyruvate, and Mg2+, overview
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-
?
additional information
?
-
the enzyme also catalzes the reversible cleavage of (S)-citramalyl-CoA to acetyl-CoA and pyruvate, reaction of EC 4.1.3.25. Malyl-CoA lyase is a promiscuous carbon-carbon bond lyase that catalyzes the reversible cleavage of structurally related CoA thioesters
-
-
?
additional information
?
-
-
the enzyme also catalzes the reversible cleavage of (S)-citramalyl-CoA to acetyl-CoA and pyruvate, reaction of EC 4.1.3.25. Malyl-CoA lyase is a promiscuous carbon-carbon bond lyase that catalyzes the reversible cleavage of structurally related CoA thioesters
-
-
?
additional information
?
-
the enzyme also catalzes the reversible cleavage of (S)-citramalyl-CoA to acetyl-CoA and pyruvate, reaction of EC 4.1.3.25
-
-
?
additional information
?
-
-
the enzyme also catalzes the reversible cleavage of (S)-citramalyl-CoA to acetyl-CoA and pyruvate, reaction of EC 4.1.3.25
-
-
?
additional information
?
-
Chloroflexus aurantiacus OK-70-fl / DSM 636
the enzyme also catalzes the reversible cleavage of (S)-citramalyl-CoA to acetyl-CoA and pyruvate, reaction of EC 4.1.3.25. Malyl-CoA lyase is a promiscuous carbon-carbon bond lyase that catalyzes the reversible cleavage of structurally related CoA thioesters
-
-
?
additional information
?
-
Chloroflexus aurantiacus OK-70-fl / DSM 636
the enzyme also catalzes the reversible cleavage of (S)-citramalyl-CoA to acetyl-CoA and pyruvate, reaction of EC 4.1.3.25
-
-
?
additional information
?
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-
the role in C1 metabolism, in organisms utilizing the Ser pathway, may be to provide the glyoxylate necessary to sustain operations of this pathway
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-
?
additional information
?
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-
the role in C1 metabolism, in organisms utilizing the Ser pathway, may be to provide the glyoxylate necessary to sustain operations of this pathway
-
-
?
additional information
?
-
-
the enzyme may serve as a route to Gly during biosynthesis of purines and proteins
-
-
?
additional information
?
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-
the role in C1 metabolism, in organisms utilizing the Ser pathway, may be to provide the glyoxylate necessary to sustain operations of this pathway
-
-
?
additional information
?
-
-
the role in C1 metabolism, in organisms utilizing the Ser pathway, may be to provide the glyoxylate necessary to sustain operations of this pathway
-
-
?
additional information
?
-
Pseudomonas methanolica
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the enzyme may serve as a route to Gly during biosynthesis of purines and proteins
-
-
?
additional information
?
-
-
the specific activity of malyl-CoA lyase is severalfold higher when grown on C1 compounds than when grown on C2, C3 or C4 compounds
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-
?
additional information
?
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-
the specific activity of malyl-CoA lyase is severalfold higher when grown on C1 compounds than when grown on C2, C3 or C4 compounds
-
-
?
additional information
?
-
-
the specific activity of malyl-CoA lyase is severalfold higher when grown on C1 compounds than when grown on C2, C3 or C4 compounds
-
-
?