4.1.2.9: phosphoketolase
This is an abbreviated version!
For detailed information about phosphoketolase, go to the full flat file.
Word Map on EC 4.1.2.9
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4.1.2.9
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pentose
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xylose
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heterofermentative
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fructose-6-phosphate
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leuconostoc
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bifidobacteria
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phosphotransacetylase
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biotechnology
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embden-meyerhof-parnas
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heterolactic
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bifid
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synthesis
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xylulokinase
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acetylphosphate
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erythrose
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acetyl-coa-derived
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bifidobacteriaceae
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industry
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pharmacology
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biofuel production
- 4.1.2.9
- pentose
- xylose
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heterofermentative
- fructose-6-phosphate
- leuconostoc
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bifidobacteria
- phosphotransacetylase
- biotechnology
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embden-meyerhof-parnas
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heterolactic
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bifid
- synthesis
- xylulokinase
- acetylphosphate
- erythrose
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acetyl-coa-derived
- bifidobacteriaceae
- industry
- pharmacology
- biofuel production
Reaction
Synonyms
CAC1343, D-xylulose 5-phosphate phosphoketolase, D-Xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase, D-Xylulose-5-phosphate phosphoketolase, FXPK, Pentulose-5-phosphate phosphoketolase, PhK, phosphoketolase, phosphoketolase-1, phosphoketolase-2, PKT, Pu5PPK, slr0453, X5P/F6P phosphoketolase, X5PPK, Xfp, XFPK, XPK, XpkA, xylulose-5-phosphate phosphoketolase, xylulose-5-phosphate/fructose-6-phosphate phosphoketolase
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Application
Application on EC 4.1.2.9 - phosphoketolase
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biofuel production
biotechnology
industry
pharmacology
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polyketide natural products play an important role in the treatment of a wide range of human physiological disorders
synthesis
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overexpression of the PktB isoform leads to a 2fold increase in intracellular acetyl-CoA concentration, and a 2.6fold yield enhancement from methane to microbial biomass and lipids compared to wild-type, increasing the potential for methanotroph lipid-based fuel production
biofuel production
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overexpression of the PktB isoform leads to a 2fold increase in intracellular acetyl-CoA concentration, and a 2.6fold yield enhancement from methane to microbial biomass and lipids compared to wild-type, increasing the potential for methanotroph lipid-based fuel production
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expression of bacterial phosphoketolase in Saccharomyces cerevisiae (that does not demonstrate efficient phosphoketolase activity naturally) can efficiently divert intracellular carbon flux toward C2-synthesis, thus showing potential to be used in metabolic engineering strategies aimed to increase yields of acetyl-CoA derived compounds
biotechnology
expression of bacterial phosphoketolase in Saccharomyces cerevisiae (that does not demonstrate efficient phosphoketolase activity naturally) can efficiently divert intracellular carbon flux toward C2-synthesis, thus showing potential to be used in metabolic engineering strategies aimed to increase yields of acetyl-CoA derived compounds
biotechnology
AJD88698.1
expression of bacterial phosphoketolase in Saccharomyces cerevisiae (that does not demonstrate efficient phosphoketolase activity naturally) can efficiently divert intracellular carbon flux toward C2-synthesis, thus showing potential to be used in metabolic engineering strategies aimed to increase yields of acetyl-CoA derived compounds
biotechnology
KHD36088.1
expression of bacterial phosphoketolase in Saccharomyces cerevisiae (that does not demonstrate efficient phosphoketolase activity naturally) can efficiently divert intracellular carbon flux toward C2-synthesis, thus showing potential to be used in metabolic engineering strategies aimed to increase yields of acetyl-CoA derived compounds
biotechnology
KRU18827.1, KRU19755.1
expression of bacterial phosphoketolase in Saccharomyces cerevisiae (that does not demonstrate efficient phosphoketolase activity naturally) can efficiently divert intracellular carbon flux toward C2-synthesis, thus showing potential to be used in metabolic engineering strategies aimed to increase yields of acetyl-CoA derived compounds
biotechnology
expression of bacterial phosphoketolase in Saccharomyces cerevisiae (that does not demonstrate efficient phosphoketolase activity naturally) can efficiently divert intracellular carbon flux toward C2-synthesis, thus showing potential to be used in metabolic engineering strategies aimed to increase yields of acetyl-CoA derived compounds
biotechnology
pathway engineering advances in a high-potential alternative route, the phosphoketolase pathway, which facilitates bypass of pyruvate decarboxylation and enables complete carbon conservation in bioprocesses targeting pentose phosphate pathway and/or acetyl-CoA-derived products
biotechnology
Bifidobacterium animalis subsp. lactis DSM 101403
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pathway engineering advances in a high-potential alternative route, the phosphoketolase pathway, which facilitates bypass of pyruvate decarboxylation and enables complete carbon conservation in bioprocesses targeting pentose phosphate pathway and/or acetyl-CoA-derived products
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the production of D-lactic acid as well as L-lactic acid is of significant importance for the practical application of polylactic acid, which is an important raw material for bioplastics that can be produced from biomass
industry
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using the Lactobacillus plantarum NCIMB 8826 strain whose L-lactate dehydrogenase gene is deficient and whose phosphoketolase gene is substituted with a heterologous transketolase gene the fermentation of optically pure D-lactic acid from arabinose is achieved
industry
industrially important enzyme in the production of L-glutamic acid, mevalonate, isoprenoid precursors and isoprene
industry
Lactiplantibacillus plantarum NCIMB 8826
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using the Lactobacillus plantarum NCIMB 8826 strain whose L-lactate dehydrogenase gene is deficient and whose phosphoketolase gene is substituted with a heterologous transketolase gene the fermentation of optically pure D-lactic acid from arabinose is achieved
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industry
Lactiplantibacillus plantarum NCIMB 8826
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the production of D-lactic acid as well as L-lactic acid is of significant importance for the practical application of polylactic acid, which is an important raw material for bioplastics that can be produced from biomass
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industry
Lactiplantibacillus plantarum NCIMB 8826 delta ldhL1 -xpk1::tkt-delta xpk
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the production of D-lactic acid as well as L-lactic acid is of significant importance for the practical application of polylactic acid, which is an important raw material for bioplastics that can be produced from biomass
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a phosphoketolase disruption mutant harboring the pXylRAB gene for catabolism of xylose lacks the phosphoketolasepathwas pathway and produces predominantly lactic acid from xylose via the pentose phosphate pathway, although its fermentation rate slightly decreases. Further introduction of the transketolase gene to disrupted phosphoketolase locus leads to restoration of the fermentation rate. As a result, the strain produces 50.1 g/l of L-lactic acid from xylose with a optical purity of 99.6% and a yield of 1.58 mol per mole xylose consumed
synthesis
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metabolic engineering strategy to express the fungal genes of the phosphoketolase pathway in Saccharomyces cerevisiae. The utilization of the phosphoketolase pathway does not interfere with glucose assimilation through the Embden-Meyerhof-Parnas pathway and the expression of this route can contribute to increase the acetyl CoA supply
synthesis
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given that acetyl-CoA is a key intermediate in several biosynthetic pathways, phosphoketolase overexpression offers a viable strategy to enhance the economics of an array of biological methane conversion processes
synthesis
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expression of mutant T2A/I6T/H260 in Corynebacterium glutamicum Z188 results in 16.67% and 18.19% improvement in L-glutamate titer and yield, respectively, compared with the wildtype
synthesis
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given that acetyl-CoA is a key intermediate in several biosynthetic pathways, phosphoketolase overexpression offers a viable strategy to enhance the economics of an array of biological methane conversion processes
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