4.1.2.55: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
This is an abbreviated version!
For detailed information about 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase, go to the full flat file.
Word Map on EC 4.1.2.55
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4.1.2.55
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sulfolobus
-
solfataricus
-
entner-doudoroff
-
hyperthermophilic
-
dehydratase
-
non-phosphorylative
-
aldolases
-
archaeon
-
galactose
-
n-acetylneuraminate
-
stereochemical
-
thermoacidophilic
-
nonphosphorylated
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picrophilus
-
acidocaldarius
-
dhdps
-
stereoselectivity
-
dihydrodipicolinate
-
torridus
-
synthesis
- 4.1.2.55
-
sulfolobus
- solfataricus
-
entner-doudoroff
-
hyperthermophilic
- dehydratase
-
non-phosphorylative
- aldolases
- archaeon
- galactose
- n-acetylneuraminate
-
stereochemical
-
thermoacidophilic
-
nonphosphorylated
-
picrophilus
- acidocaldarius
- dhdps
-
stereoselectivity
- dihydrodipicolinate
- torridus
- synthesis
Reaction
Synonyms
2-keto-3-deoxy-6-phosphogluconate aldolase, 2-keto-3-deoxygluconate aldolase, KD(P)G-aldolase, KDG aldolase, KDG-aldolase, KDGA, SacKdgA
ECTree
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.1.2.55 - 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-dehydro-3-deoxy-6-phospho-D-gluconate
pyruvate + D-glyceraldehyde 3-phosphate
preferred substrate
-
-
?
2-dehydro-3-deoxy-D-galactonate
pyruvate + D-glyceraldehyde
-
-
-
?
2-dehydro-3-deoxy-D-galactonate
pyruvate + D-glyceraldehyde
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-galactonate
pyruvate + D-glyceraldehyde
the same enzyme is responsible for the catabolism of both glucose and galactose
-
-
?
2-dehydro-3-deoxy-D-galactonate
pyruvate + D-glyceraldehyde
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-galactonate
pyruvate + D-glyceraldehyde
-
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-galactonate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
-
-
-
?
2-dehydro-3-deoxy-D-galactonate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-galactonate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-galactonate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
-
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-gluconate
pyruvate + D-glyceraldehyde
-
-
-
?
2-dehydro-3-deoxy-D-gluconate
pyruvate + D-glyceraldehyde
comparison of the catalytic efficiency (kcat/KM) for 2-dehydro-3-deoxy-D-gluconate (1.1 mM/s) and 2-dehydro-3-deoxy-D-gluconate 6-phosphate (643 mM/s) suggests that cleavage of the phosphorylated substrate would be significantly favoured in a situation where both compounds are present. If the 2-dehydro-3-deoxy-D-gluconate kinase is present and active then central metabolism will occur via the part-phosphorylative route.The Km of the kinase for ATP of 2.8 mM is high compared to the likely intracellular concentration, and it is possible that the non-phosphorylative pathway would be favoured under starvation conditions, which could produce pyruvate to allow the citric acid cycle to function without ATP input. regardless of whether Sulfolobus solfataricus uses the part-phosphorylative or the non-phosphorylative Entner-Doudoroff pathway, then the same enzymes can be used for the metabolism of glucose and its C4 epimer galactose
-
-
?
2-dehydro-3-deoxy-D-gluconate
pyruvate + D-glyceraldehyde
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-gluconate
pyruvate + D-glyceraldehyde
the same enzyme is responsible for the catabolism of both glucose and galactose
-
-
?
2-dehydro-3-deoxy-D-gluconate
pyruvate + D-glyceraldehyde
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-gluconate
pyruvate + D-glyceraldehyde
-
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-gluconate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
-
-
-
?
2-dehydro-3-deoxy-D-gluconate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-gluconate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-gluconate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
-
key enzyme in both the non- and the semi-phosphorylative EntnerDoudoroff pathway
-
-
?
2-dehydro-3-deoxy-D-xylonate
pyruvate + glycolaldehyde
non-phosphorylative Entner-Doudoroff pathway for catabolism of D-xylose and L-arabinose
-
-
?
2-dehydro-3-deoxy-D-xylonate
pyruvate + glycolaldehyde
non-phosphorylative Entner-Doudoroff pathway for catabolism of D-xylose and L-arabinose
-
-
?
2-dehydro-3-deoxy-L-arabinonate
pyruvate + glycolaldehyde
non-phosphorylative Entner-Doudoroff pathway for catabolism of D-xylose and L-arabinose
-
-
?
2-dehydro-3-deoxy-L-arabinonate
pyruvate + glycolaldehyde
non-phosphorylative Entner-Doudoroff pathway for catabolism of D-xylose and L-arabinose
-
-
?
