4.1.2.52: 4-hydroxy-2-oxoheptanedioate aldolase

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For detailed information about 4-hydroxy-2-oxoheptanedioate aldolase, go to the full flat file.

Reaction

Synonyms

4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, HpaI, HpcH

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase

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Results	in table
2354	AA Sequence
3	Cloned(Commentary)
4	Crystallization (Commentary)
2	General Information
1	General Stability
7	Inhibitors
18	kcat/KM [mM/s]
8	Ki Value [mM]
24	KM Value [mM]
12	Metals/Ions
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
5	Organism
6	Pathway
6	PDB ID
1	pH Range
8	Protein Variants
3	Purification (Commentary)
2	Reaction
5	Reference
19	Substrates and Products (Substrate)
2	Subunits
7	Synonyms
1	Systematic Name
19	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.1.2.52 - 4-hydroxy-2-oxoheptanedioate aldolase

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SYSTEMATIC NAME

IUBMB Comments

4-hydroxy-2-oxoheptanedioate succinate semialdehyde lyase (pyruvate-forming)

Requires Co2+ or Mn2+ for activity. The enzyme is also able to catalyse the aldol cleavage of 4-hydroxy-2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency. In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate. The enzyme from the bacterium Escherichia coli produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate [4].