4.1.2.52: 4-hydroxy-2-oxoheptanedioate aldolase
This is an abbreviated version!
For detailed information about 4-hydroxy-2-oxoheptanedioate aldolase, go to the full flat file.
Reaction
Synonyms
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, HpaI, HpcH
ECTree
4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolaseAdvanced search results
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results (Metals Ions
Metals Ions on EC 4.1.2.52 - 4-hydroxy-2-oxoheptanedioate aldolase
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METALS and IONS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Cd2+
0.5 mM chloride salt, 4% relative activity, with 4-hydroxy-2-oxopentanoate as substrate
Co2+
Cu2+
0.5 mM chloride salt, 1% relative activity, with 4-hydroxy-2-oxopentanoate as substrate
Fe2+
0.5 mM chloride salt, 57% relative activity, with 4-hydroxy-2-oxopentanoate as substrate
Mg2+
0.5 mM chloride salt, 49% relative activity, with 4-hydroxy-2-oxopentanoate as substrate
Mn2+
0.5 mM chloride salt, 99% relative activity, with 4-hydroxy-2-oxopentanoate as substrate
Ni2+
0.5 mM chloride salt, 11% relative activity, with 4-hydroxy-2-oxopentanoate as substrate
Zn2+
0.5 mM chloride salt, 73% relative activity, with 4-hydroxy-2-oxopentanoate as substrate
additional information
Co2+
0.5 mM chloride salt, 100% relative activity, with 4-hydroxy-2-oxopentanoate as substrate
additional information
H45A and H45Q mutant enzymes have 24fold and 69fold higher dissociation constants for Co2+ compared to the wild-type enzyme
