4.1.2.51: 2-dehydro-3-deoxy-D-gluconate aldolase

This is an abbreviated version!
For detailed information about 2-dehydro-3-deoxy-D-gluconate aldolase, go to the full flat file.

Reaction

Synonyms

KDG-specific aldolase, KDGA, Pto1279

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase

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Results	in table
45	AA Sequence
1	Cloned(Commentary)
1	General Information
4	kcat/KM [mM/s]
6	KM Value [mM]
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
1	Organism
7	Pathway
4	PDB ID
2	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
1	Reference
1	Specific Activity [micromol/min/mg]
5	Substrates and Products (Substrate)
1	Subunits
3	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Stability [°C]
4	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.1.2.51 - 2-dehydro-3-deoxy-D-gluconate aldolase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-dehydro-3-deoxy-D-galactonate

pyruvate + D-glyceraldehyde

2 entries

2-dehydro-3-deoxy-D-gluconate

pyruvate + D-glyceraldehyde

2 entries

2-dehydro-3-deoxy-D-gluconate 6-phosphate

pyruvate + D-glyceraldehyde 3-phosphate

Picrophilus torridus

Q6KZI8

highly specific for 2-dehydro-3-deoxy-D-gluconate with up to 2000fold-higher catalytic efficiency compared to 2-dehydro-3-deoxy-6-phosphogluconate

704334

-

-

?

2-dehydro-3-deoxy-D-galactonate

pyruvate + D-glyceraldehyde

Picrophilus torridus

Q6KZI8

-

704334

-

-

?

2-dehydro-3-deoxy-D-galactonate

pyruvate + D-glyceraldehyde

Picrophilus torridus

Q6KZI8

the enzyme shows substrate promiscuity, as measured in the direction of aldol synthesis. The enzyme catalyzes the formation of both 2-dehydro-3-deoxy-D-gluconate and its C-4 epimer 2-keto-3-deoxygalactonate from D- or L-glyceraldehyde and pyruvate at a similar ratio, indicating lack of stereospecific control in formation and cleavage of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate

704334

-

-

r

2-dehydro-3-deoxy-D-gluconate

pyruvate + D-glyceraldehyde

Picrophilus torridus

Q6KZI8

the enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway

704334

-

-

?

2-dehydro-3-deoxy-D-gluconate

pyruvate + D-glyceraldehyde

Picrophilus torridus

Q6KZI8

highly specific for 2-dehydro-3-deoxy-D-gluconate with up to 2000fold-higher catalytic efficiency compared to 2-dehydro-3-deoxy-6-phosphogluconate

704334

-

-

?