4.1.2.50: 6-carboxytetrahydropterin synthase

This is an abbreviated version!
For detailed information about 6-carboxytetrahydropterin synthase, go to the full flat file.

Reaction

Synonyms

6-carboxy-5,6,7,8-tetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase, CPH4 synthase, PTPS, QueD

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.50 6-carboxytetrahydropterin synthase

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Results	in table
17166	AA Sequence
2	Cloned(Commentary)
3	Crystallization (Commentary)
2	General Information
1	Metals/Ions
1	Natural Substrates/ Products (Substrates)
4	Organism
5	Pathway
30	PDB ID
8	Protein Variants
2	Purification (Commentary)
2	Reaction
4	Reference
6	Substrates and Products (Substrate)
1	Subunits
10	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 4.1.2.50 - 6-carboxytetrahydropterin synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

6-pyruvoyltetrahydropterin + H2O

6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

Escherichia coli

-

-

702280

-

-

?

7,8-dihydroneopterin 3'-triphosphate + H2O

6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

Escherichia coli

P65870

-

748175

-

-

?

7,8-dihydroneopterin triphosphate + H2O

6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

Escherichia coli

-

-

702280

-

-

?

sepiapterin + H2O

6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

Escherichia coli

-

-

702280

-

-

?

sepiapterin + H2O

?

Escherichia coli

P65870

-

748175

-

-

?

additional information

?

-

Escherichia coli

-

6-pyruvoyltetrahydropterin can tautomerize to sepiapterin, the hydrate of which undergoes carbon-carbon bond cleavage by an aldolase-like mechanism, followed by a tautomerization, to yield 6-carboxy-5,6,7,8-tetrahydropterin

702280

-

-

?