4.1.2.48: low-specificity L-threonine aldolase

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For detailed information about low-specificity L-threonine aldolase, go to the full flat file.

Reaction

Synonyms

GLY1, GlyA, L-TA, L-threonine aldolase, low specificity L-TA, low specificity threonine aldolase, Low-specificity L-threonine aldolase, LTA, LtaE, serine hydroxy-methyl transferase, SHMT, threonine aldolase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.48 low-specificity L-threonine aldolase

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Results	in table
3	Activating Compound
8609	AA Sequence
5	Application
10	Cloned(Commentary)
11	Cofactor
5	Crystallization (Commentary)
4	General Information
5	Inhibitors
41	kcat/KM [mM/s]
70	KM Value [mM]
1	Metals/Ions
13	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
117	Organism
6	Pathway
6	PDB ID
15	pH Optimum
3	pH Stability
56	Protein Variants
7	Purification (Commentary)
2	Reaction
25	Reference
6	Specific Activity [micromol/min/mg]
77	Substrates and Products (Substrate)
7	Subunits
24	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
5	Temperature Stability [°C]
47	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.1.2.48 - low-specificity L-threonine aldolase

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SYSTEMATIC NAME

IUBMB Comments

L-threonine/L-allo-threonine acetaldehyde-lyase (glycine-forming)

Requires pyridoxal phosphate. The low-specificity L-threonine aldolase can act on both L-threonine and L-allo-threonine [1,2]. The enzyme from Escherichia coli can also act on L-threo-phenylserine and L-erythro-phenylserine [4]. The enzyme can also catalyse the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis [3]. Different from EC 4.1.2.5, L-threonine aldolase, and EC 4.1.2.49, L-allo-threonine aldolase.