4.1.2.48: low-specificity L-threonine aldolase
This is an abbreviated version!
For detailed information about low-specificity L-threonine aldolase, go to the full flat file.
Reaction
Synonyms
GLY1, GlyA, L-TA, L-threonine aldolase, low specificity L-TA, low specificity threonine aldolase, Low-specificity L-threonine aldolase, LTA, LtaE, serine hydroxy-methyl transferase, SHMT, threonine aldolase
ECTree
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Cofactor
Cofactor on EC 4.1.2.48 - low-specificity L-threonine aldolase
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pyridoxal 5'-phosphate
-
contains 6 mol of pyridoxal 5'-phosphate per mol of enzyme
pyridoxal 5'-phosphate
2 mol pyridoxal 5'-phosphate per 4 mol of subunit
pyridoxal 5'-phosphate
contains 1 mol of pyridoxal 5'-phosphate as cofactor per mol of 36500 Da subunit
pyridoxal 5'-phosphate
contains 1 mol of pyridoxal 5'-phosphate per mol of 38000 da subunit. Lys207 probably functions as an essential catalytic residue, forming an internal Schiff base with the pyridoxal 5'-phosphate of the enzyme to catalyze the reversible aldol reaction
pyridoxal 5'-phosphate
-
Km: 0.00025 mM, 1 mol of pyridoxal phosphate binds 46000 g of protein