4.1.2.43: 3-hexulose-6-phosphate synthase

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For detailed information about 3-hexulose-6-phosphate synthase, go to the full flat file.

Reaction

Synonyms

3-hexulose phosphate synthase, 3-hexulose-6-phosphate formaldehyde lyase, 3-hexulose-6-phosphate synthase, 3-hexulose-phosphate synthase, 3-hexulosephosphate synthase, D-arabino-3-hexulose 6-phosphate formaldehyde lyase, D-arabino-3-hexulose 6-phosphate formaldehyde-lyase, Fae-Hps, hexose phosphate synthase, hexulose-6-phosphate synthase, HPS, HPS-aldolase, HPS-PHI, HPS/PHI

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.43 3-hexulose-6-phosphate synthase

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2	Activating Compound
2492	AA Sequence
4	Application
1	CAS Registry Number
15	Cloned(Commentary)
1	Crystallization (Commentary)
22	General Information
28	Inhibitors
2	kcat/KM [mM/s]
43	KM Value [mM]
81	Metals/Ions
38	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
249	Organism
11	Pathway
4	PDB ID
8	pH Optimum
2	pH Stability
1	pI Value
20	Protein Variants
17	Purification (Commentary)
1	Reaction
2	Reaction Type
88	Reference
24	Specific Activity [micromol/min/mg]
4	Storage Stability
126	Substrates and Products (Substrate)
38	Subunits
152	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
14	Temperature Stability [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.1.2.43 - 3-hexulose-6-phosphate synthase

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SYSTEMATIC NAME

IUBMB Comments

D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)

Requires Mg2+ or Mn2+ for maximal activity [1]. The enzyme is specific for D-ribulose 5-phosphate as substrate as ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. In addition to formaldehyde, the enzyme can also use glycolaldehyde and methylglyoxal [7]. This enzyme, along with EC 5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC 5.3.1.27, 6-phospho-3-hexuloisomerase [6]. This enzyme is a member of the orotidine 5'-monophosphate decarboxylase (OMPDC) suprafamily [5].