Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.1.2.32: trimethylamine-oxide aldolase

This is an abbreviated version!
For detailed information about trimethylamine-oxide aldolase, go to the full flat file.

Word Map on EC 4.1.2.32

Reaction

Trimethylamine N-oxide
=
Dimethylamine
+
formaldehyde

Synonyms

TMAO demethylase, TMAOase, Trimethylamine N-oxide aldolase, Trimethylamine N-oxide demethylase, Trimethylamine N-oxide formaldehyde-lyase, trimethylamine oxide aldolase, trimethylamine-N-oxide demethylase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.32 trimethylamine-oxide aldolase

Inhibitors

Inhibitors on EC 4.1.2.32 - trimethylamine-oxide aldolase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetate
-
97.1% inhibition at 10 mM
ascorbate
-
activity stimulated by NADH and FMN (anaerobic) is inhibited by 40%
cyanide
FeCl2
-
activity stimulated by NADH and FMN (anaerobic) is inhibited by 95% in the presence of 0.2 mM FeCl2, inhibition cannot be relieved by the presence of EDTA. Activity stimulated by ascorbate is inhibited by 94% in the presence of 0.2 mM FeCl2
FMN
-
30% inhibition in the presence of Fe2+, cysteine, and ascorbate
iodoacetamide
-
pre-incubation results in 25% loss of activity in both cofactor systems
mercaptoethanol
-
96% inhibition at concentration of 20 mM
Mercurials
-
active at 0.001 mM
-
NaN3
-
100% inhibition of NADH/FMN cofactor system (anaerobic conditions), 40% inhibition of the ascorbate/cysteine/Fe2+ cofactor system under anaerobic conditions
phytic acid
-
95.6% inhibition at 10 mM
Proadifen hydrochloride
-
i.e. SKF 525-A, , competitive
tea polyphenol
-
98.6% inhibition at 10 mM
Triethylamine N-oxide
-
-
trimethylamine
Urea
-
about 100% inhibition at concentration of 4 mM
additional information
-