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4.1.2.14: 2-dehydro-3-deoxy-phosphogluconate aldolase

This is an abbreviated version!
For detailed information about 2-dehydro-3-deoxy-phosphogluconate aldolase, go to the full flat file.

Word Map on EC 4.1.2.14

Reaction

2-dehydro-3-deoxy-6-phospho-D-gluconate
=
pyruvate
+
D-glyceraldehyde 3-phosphate

Synonyms

2-dehydro-3-deoxy-phosphogluconate aldolase, 2-dehydro-3-deoxyphosphogluconate aldolase, 2-keto-3-deoxy-(6-phospho)-gluconate aldolase, 2-keto-3-deoxy-6-phosphogluconate aldolase, 2-keto-3-deoxy-6-phosphogluconic aldolase, 2-keto-3-deoxygluconate-6-P-aldolase, 2-keto-3-deoxygluconate-6-phosphate aldolase, 2-oxo-3-deoxy-6-phosphogluconate aldolase, 6-phospho-2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-3-phosphate-lyase, 6-Phospho-2-keto-3-deoxygluconate aldolase, aldolase, phospho-2-keto-3-deoxygluconate, eda, KD(P)G aldolase, KDGA, KDPG aldolase, KDPG-aldolase, KDPGA, KDPGlc aldolase, ODPG aldolase, Phospho-2-dehydro-3-deoxygluconate aldolase, Phospho-2-keto-3-deoxygluconate aldolase, Phospho-2-keto-3-deoxygluconic aldolase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase

Substrates Products

Substrates Products on EC 4.1.2.14 - 2-dehydro-3-deoxy-phosphogluconate aldolase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(4S)-2-oxo-4-hydroxy-4-(2'-pyridyl)butanoate
?
show the reaction diagram
-
-
-
-
r
2-dehydro-3-deoxy-6-phospho-D-galactonate
?
show the reaction diagram
2-dehydro-3-deoxy-6-phospho-D-gluconate
pyruvate + D-glyceraldehyde 3-phosphate
show the reaction diagram
2-dehydro-3-deoxy-D-galactonate
pyruvate + D-glyceraldehyde
show the reaction diagram
-
-
-
-
?
2-dehydro-3-deoxy-D-galactonate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
show the reaction diagram
-
-
-
-
?
2-dehydro-3-deoxy-D-gluconate
?
show the reaction diagram
-
-
-
-
?
2-dehydro-3-deoxy-D-gluconate
pyruvate + ?
show the reaction diagram
-
-
-
?
2-dehydro-3-deoxy-D-gluconate
pyruvate + D-glyceraldehyde
show the reaction diagram
2-dehydro-3-deoxy-D-gluconate 6-phosphate
pyruvate + D-glyceraldehyde 3-phosphate
show the reaction diagram
2-dehydro-4-hydroxy-4-(2'-pyridyl)butyrate
?
show the reaction diagram
-
-
-
-
?
2-dehydro-4-hydroxyoctonate
?
show the reaction diagram
-
-
-
-
?
2-keto-3-deoxy-6-phosphogalactonate
?
show the reaction diagram
-
-
-
-
?
2-oxobutyrate + 2-pyridine carboxaldehyde
?
show the reaction diagram
weak substrate for wild-type enzyme, good substrate for K133Q/T161K mutant
-
?
2-oxobutyrate + D-glyceraldehyde
?
show the reaction diagram
-
weak substrate
-
?
2-pyridinecarboxyaldehyde + pyruvate
(S)-4-hydroxy-2-keto-4-(2'-pyridyl)butyrate
show the reaction diagram
-
typical isolated yield of product is 80-90% after reverse-phase C18 purification. Reaction is also doable with substrates other than 2-pyridinecarboxyaldehyde. Enantiomeric excess greater than 99.7%
-
-
?
3-fluoropyruvate + 2-pyridine carboxaldehyde
?
show the reaction diagram
weak substrate for wild-type enzyme, good substrate for K133Q/T161K mutant
-
?
3-fluoropyruvate + D-glyceraldehyde
?
show the reaction diagram
-
weak substrate
-
?
4-hydroxy-2-oxooctonate
?
show the reaction diagram
-
-
-
-
r
D-2-dehydro-3-deoxygluconate
pyruvate + D-glyceraldehyde
show the reaction diagram
-
poor substrate
-
?
pyruvate + 2-pyridine carboxaldehyde
?
show the reaction diagram
pyruvate + 3-pyridine carboxaldehyde
?
show the reaction diagram
-
wild-type, 0.5% of activity with D-glyceraldehyde 3-phosphate, mutant T161S/S184L, 1% of wild-type activity with D-glyceraldehyde 3-phosphate
-
-
r
pyruvate + 4-pyridine carboxaldehyde
?
show the reaction diagram
-
wild-type, 3% of activity with D-glyceraldehyde 3-phosphate, mutant T161S/S184L, 2.5% of wild-type activity with D-glyceraldehyde 3-phosphate
-
-
r
pyruvate + benzaldehyde
?
show the reaction diagram
-
-
?
pyruvate + D-erythrose
?
show the reaction diagram
Pyruvate + D-erythrose 4-phosphate
3-Deoxy-D-riboheptulosonic acid 7-phosphate
show the reaction diagram
-
28% of the activity with D-glyceraldehyde 3-phosphate
-
?
pyruvate + D-glyceraldehyde
2-dehydro-3-deoxy-D-gluconate
show the reaction diagram
Pyruvate + D-glyceraldehyde
?
show the reaction diagram
-
35% of the activity with D-glyceraldehyde 3-phosphate
-
-
?
pyruvate + D-glyceraldehyde 3-phosphate
2-dehydro-3-deoxy-6-phospho-D-gluconate
show the reaction diagram
Pyruvate + D-glyceraldehyde 3-phosphate
6-Phospho-2-dehydro-3-deoxy-D-gluconate
show the reaction diagram
pyruvate + D-lactaldehyde
?
show the reaction diagram
-
-
-
?
pyruvate + D-threose
?
show the reaction diagram
-
weak substrate
-
?
pyruvate + DL-3-fluoro-2-hydroxypropanal
?
show the reaction diagram
-
-
-
?
pyruvate + DL-glyceraldehyde 3-phosphate
2-dehydro-3-deoxy-D-gluconate
show the reaction diagram
-
-
-
?
pyruvate + glycoaldehyde
?
show the reaction diagram
pyruvate + glyoxylate
(4S)-4-hydroxy-2-oxoglutarate
show the reaction diagram
-
-
-
r
Pyruvate + glyoxylate
?
show the reaction diagram
-
-
-
?
Pyruvate + glyoxylic acid
?
show the reaction diagram
-
93% of the activity with D-glyceraldehyde 3-phosphate
-
-
?
pyruvate + L-erythrose
?
show the reaction diagram
-
weak substrate
-
?
pyruvate + L-glyceraldehyde 3-phosphate
?
show the reaction diagram
-
weak substrate
-
?
pyruvate + L-threose
?
show the reaction diagram
-
weak substrate
-
?
additional information
?
-