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4.1.2.13: fructose-bisphosphate aldolase

This is an abbreviated version!
For detailed information about fructose-bisphosphate aldolase, go to the full flat file.

Word Map on EC 4.1.2.13

Reaction

D-fructose 1,6-bisphosphate
=
glycerone phosphate
 +
D-glyceraldehyde 3-phosphate

Synonyms

1,6-Diphosphofructose aldolase, 37 kDa major allergen, 41 kDa antigen, ALD, ALDC, aldoA, Aldob, aldolase, aldolase A, aldolase B, aldolase C, aldolase, fructose diphosphate, ALDP, bifunctional fructose-1,6-bisphosphate aldolase/phosphatase, Brain-type aldolase, Ca-FBA-II, CE1, CE2, class I Fba, class I fructose 1,6-bisphosphate aldolase, class I fructose bisphosphate aldolase, class I fructose-1,6-bisphosphate aldolase, class I muscle fructose bis-phosphate aldolase, class II aldolase, class II FBA, class II FBP aldolase, class II fructose 1,6-bisphosphate aldolase, class II fructose bisphosphate aldolase, class II fructose-1,6-bisphosphate aldolase, class IIa fructose 1,6-bisphosphate aldolase, class IIb fructose 1,6-bisphosphate aldolase, ClassII FBP-aldolase, CoFBA1, CoFBA2, CoFBA3, CoFBA4, D-fructose-1,6-bisphosphate aldolase, D-fructose-1,6-bisphosphate D-glyceraldehyde-3-P-lyase, D-fructose-6-phosphate aldolase, Diphosphofructose aldolase, DLF, EC 4.1.2.7, F1,6-P2 aldolase, F1,6P2 aldolase, F16BP aldolase, FBA, FBA class II, FBA-II, Fba1, Fba1p, Fba2, FBA7, FbaA, FbaB, FbaC, FBAld, FbaP, FBP aldolase, FBP aldolase/phosphatase, FBP-aldolase, FBPA, FBPA I, FBPA-1, FBPA/P, FDP aldolase, FPA, Fru-1,6-P2 aldolase, Fru-P2A, Fructoaldolase, fructose 1,6 bisphosphate aldolase, fructose 1,6-bisphosphatase/aldolase, Fructose 1,6-bisphosphate aldolase, fructose 1,6-bisphosphate aldolase/phosphatase, Fructose 1,6-diphosphate aldolase, Fructose 1-monophosphate aldolase, Fructose 1-phosphate aldolase, fructose bis-phosphate aldolase, Fructose bisphosphate aldolase, Fructose diphosphate aldolase, fructose-1,6-biphosphate aldolase, fructose-1,6-bisphosphate (FBP) aldolase/phosphatase, fructose-1,6-bisphosphate aldolase, fructose-1,6-bisphosphate aldolase A, fructose-1,6-bisphosphate aldolase B, fructose-1,6-bisphosphate aldolase class II, fructose-1,6-bisphosphate aldolase/phosphatase, fructose-1,6-bisphosphate muscle aldolase, Fructose-1,6-bisphosphate triosephosphate-lyase, fructose-bisphosphate aldolase, fructose-bisphosphate aldolase A, FSA, fuculose aldolase, heat-induced protein 44, HIP44, IgE-binding allergen, ketose 1-phosphate aldolase, Leishmania aldolase, Liver-type aldolase, MGA3_01355, MJ0400-His6, More, MtFBA, Muscle-type aldolase, Ov-fba-1, OvFBPA-1, Pcal_0111, Phosphofructoaldolase, SMALDO, SSO0286, STK_03180, TgALD1, Tneu_0133, TnFBPAP, Tt-FBPA, zerebrin II, zymohexase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.13 fructose-bisphosphate aldolase

Expression

Expression on EC 4.1.2.13 - fructose-bisphosphate aldolase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
abiotic stimuli such as seawater, 500 mM/l NaCl, 0.1 M abscisic acid, and PEG 8000 (20% w/v) can trigger a significant induction of FBA in Sesuvium portulacastrum roots within 2-12 h
ALDOA expression is upregulated under hypoxic conditions
constitutively expressed at steady state levels in all developmental stages
enzyme expression is upregulated under hypoxic conditions
expression level of both isoforms A and B increases in liver tissue to 1.6fold after 20 h anoxia, without significant change in the ratio of isoforms
-
highly increased transcript levels of fba in fructose-grown cells compared to those in glucose-grown cells, indicating fructosespecific upregulation
in more mature seeds collected in late October, the expression levels is slightly down-regulated
isoform FBA1 transcript levels are specifically reduced by abiotic stress
-
mRNA levels is low but detectable at the initial oil synthesis stage (May 5 sample), gradually increases during the next two months, upregulates sharply in early September and reaches peak levels in late September
mRNA levels is low but detectable at the initial oil synthesis stage (May 5 sample), gradually increases during the next two months, upregulates sharply in early September and reaches peak levels in late September. In more mature seeds collected in late October the expression level is still increased
on stimulation with epidermal growth factor, the wound recovery area and ALDOA and its mRNA levels increase
-
protein is produced under various axenic growth conditions including oxygen depletion and hence by non-replicating bacilli, and also in vivo in the lungs of infected guinea pigs and mice. Enzyme binds human plasmin(ogen) and protects bound plasmin from regulation by alpha2-antiplasmin
the expression of isoform fbaB is negatively regulated by a key hrp regulatory HrpG and HrpX cascade, the hrp genes encoding a type-III secretion system, enable bacterial pathogens to trigger a rapid, localized, programmed hypersensitive response in nonhost plants and become pathogenic in hosts. The expression of hrpG and hrpX is repressed and the transcripts of hrcC, hrpE and hpa3 are enhanced when fbaB is deleted
-