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4.1.1.97: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

This is an abbreviated version!
For detailed information about 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.97

Reaction

5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
=
(S)-allantoin
+
CO2

Synonyms

hpxQ, OHCU decarboxylase, PRHOXNB, Uro3

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.97 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

Engineering

Engineering on EC 4.1.1.97 - 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Q88E
the maximal rate of this mutant is 43fold slower than that of the native rate, whereas the measured Km for the mutant is similar to that of the native enzyme, the kcat/Km value is about 50fold lower than the wild-type value