4.1.1.94: ethylmalonyl-CoA decarboxylase
This is an abbreviated version!
For detailed information about ethylmalonyl-CoA decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.94
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4.1.1.94
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acetyl-coa
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aciduria
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branched-chain
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propionyl-coa
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ethylmalonic
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polyhydroxyalkanoates
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butyryl-coa
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proofreading
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itraq
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crotonyl-coa
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methyl-branched
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poly3-hydroxybutyrate-co-3-hydroxyhexanoate
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hydratase
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medicine
- 4.1.1.94
- acetyl-coa
-
aciduria
-
branched-chain
- propionyl-coa
-
ethylmalonic
- polyhydroxyalkanoates
- butyryl-coa
-
proofreading
-
itraq
- crotonyl-coa
-
methyl-branched
-
poly3-hydroxybutyrate-co-3-hydroxyhexanoate
-
hydratase
- medicine
Reaction
Synonyms
ECHDC1, ethylmalonyl-CoA decarboxylase
ECTree
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General Information
General Information on EC 4.1.1.94 - ethylmalonyl-CoA decarboxylase
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malfunction
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enzyme mutation may be involved in the development of certain forms of ethylmalonic aciduria
metabolism
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ethylmalonyl-CoA decarboxylase may correct a side activity of acetyl-CoA carboxylase
physiological function
additional information
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ECHDC1-specific siRNAs decrease the ethylmalonyl-CoA decarboxylase activity in human cells and increase the formation of ethylmalonate, most particularly in cells incubated with butyrate
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ethylmalonyl-CoA decarboxylase may correct a side activity of acetyl-CoA carboxylase
physiological function
ECHDC1 expression is increased in gemcitabine-resistant bladder cancer cells, and is involved in their cell growth. Silencing of ECHDC1 significantly inhibits the proliferation of a gemcitabine-resistant UMUC-3-derived cell line. Silencing of ECHDC1 induces upregulation of p27, which is critical for cell cycle arrest in the G1 phase, and induces G1 arrest