4.1.1.9: malonyl-CoA decarboxylase
This is an abbreviated version!
For detailed information about malonyl-CoA decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.9
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4.1.1.9
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carnitine
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malonic
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amp-activated
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palmitoyltransferase
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aciduria
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goose
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uropygial
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methylmalonyl-coa
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methylmalonic
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medicine
- 4.1.1.9
- carnitine
-
malonic
-
amp-activated
- palmitoyltransferase
-
aciduria
- goose
-
uropygial
- methylmalonyl-coa
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methylmalonic
- medicine
Reaction
Synonyms
Acyl-CoA: malonate CoA transferase/malonyl-CoA decarboxylase, Decarboxylase, malonyl coenzyme A, hMCD, malonyl CoA decarboxylase, Malonyl coenzyme A decarboxylase, Malonyl-CoA decarboxylase, malonyl-CoA decarboxylase/acetyltransferase, malonyl-coenzyme A decarboxylase, MCD, MLYCD
ECTree
4.1.1.9 malonyl-CoA decarboxylaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.1.1.9 - malonyl-CoA decarboxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
N-hydroxy-L-ornithine + malonyl-CoA
delta-N-acetyl-delta-N-hydroxy-L-ornithine + coenzyme A + CO2
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acetylation of the delta-amino functionality of N-hydroxy-L-ornithine is mediated by the bifunctional malonyl-CoA decarboxylase/acetyltransferase Mcd
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-
?
Malonyl-CoA
?
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discussion of the probable role of the enzyme in the regulation of lipid metabolism, especially branched-chain fatty acid synthesis
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-
?
Malonyl-CoA
?
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the decarboxylase gene transcript levels show the developmental changes expected from the proposed role for this enzyme in the production of the secretory lipid of the uropygial glands
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-
?
Malonyl-CoA
?
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decarboxylates malonyl-CoA generated by propionyl-CoA carboxylase and thus protects mitochondrial enzymes susceptible to inhibition by malonyl-CoA
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-
?
Malonyl-CoA
?
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the main physiological role is thought to be the stabilization of malonyl-CoA levels which change very little with brain growth
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-
?
Malonyl-CoA
?
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heart enzyme has an important role in regulating fatty acid oxidation rates
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-
?
Malonyl-CoA
?
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malonyl-decarboxylase activity is induced by treatment of fatty acid synthetase with iodoacetamide
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-
?
Malonyl-CoA
?
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the increase and decrease in the decarboxylase correlates with the rate of production of erythromycin, suggesting a possible role for this enzyme in the antibiotic production
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-
?
Malonyl-CoA
?
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decarboxylase provides propionyl-CoA for erythromycin synthesis probably via decarboxylation of methylmalonyl-CoA derived from succinyl-CoA
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-
?
Malonyl-CoA
Acetyl-CoA + CO2
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-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
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plays a critical role in fatty-acid metabolism, precursor hMCD plays a role in the regulation of the cytosolic malonyl-CoA level in cells
-
?
Malonyl-CoA
Acetyl-CoA + CO2
-
malonyl-CoA degradation, transcriptional control of MCD by peroxisome proliferator-activated receptor alpha, involved in the regulation of fatty acid oxidation
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?
Malonyl-CoA
Acetyl-CoA + CO2
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MCD degrades the natural CPT1 inhibitor malonyl-CoA and thereby facilitates fatty acid import into mitochondria
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-
?
Malonyl-CoA
Acetyl-CoA + CO2
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-
-
-
?
Malonyl-CoA
Acetyl-CoA + CO2
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control of malonyl-CoA concentration
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?
Malonyl-CoA
Acetyl-CoA + CO2
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degradation of malonyl-CoA, MCD is regulated both transcriptionally and posttranscriptionally, fatty acids induce MCD gene expression
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?
Malonyl-CoA
Acetyl-CoA + CO2
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important role in regulating fatty acid metabolism, involved in the control of cellular malonyl-CoA levels, may play an essential role in regulating energy utilization in the liver by regulating malonyl-CoA levels in response to various nutritional or pathological states, MCD regulation from liver
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?
Malonyl-CoA
Acetyl-CoA + CO2
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important role in the regulation of malonyl-CoA concentration, role in the regulation of fatty-acid oxidation, may play a role in lipid catabolism by peroxisomal-proliferator-activated receptor alpha, which transcriptionally regulates the MCD gene
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?
Malonyl-CoA
Acetyl-CoA + CO2
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involved in the control of fatty acid oxidation, contributes to the high fatty acid oxidation rates in the diabetic heart
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?
Malonyl-CoA
Acetyl-CoA + CO2
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main route for the disposal of malonyl-CoA, the key metabolite in the regulation of mitochondrial fatty acid oxidation
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?
Malonyl-CoA
Acetyl-CoA + CO2
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may be implicated in the regulation of lipid metabolism and other cellular functions, involved in the regulation of the cellular malonyl-CoA level, may play an essential role in regulating energy utilization in response to various nutritional changes and/or pathological states
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?
Malonyl-CoA
Acetyl-CoA + CO2
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role in detoxification by preventing malonyl-CoA accumulation catalysed by propionyl -CoA carboxylase, in pancreatic beta cells MCD might act as an off signal for insulin release
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?
Malonyl-CoA
Acetyl-CoA + CO2
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primary substrate, higher specific activity than with methylmalonyl-CoA as substrate, Cys-214 is located at or near the active site and plays a critical role in catalysis
-
?
methylmalonyl-CoA
propionyl-CoA + CO2
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at less than 7% of the activity with malonyl-CoA
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-
?
methylmalonyl-CoA
propionyl-CoA + CO2
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at 5% of the activity with malonyl-CoA
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-
?
methylmalonyl-CoA
propionyl-CoA + CO2
Mycobacterium tuberculosis H37Ra / ATCC 25177
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at 5% of the activity with malonyl-CoA
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-
?
methylmalonyl-CoA
propionyl-CoA + CO2
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specific activity is 0.1% that of malonyl-CoA decarboxylation
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?
methylmalonyl-CoA
propionyl-CoA + CO2
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the (R)-isomer is decarboxylated at 3% of the rate observed with malonyl-CoA, the (S)-isomer is not a substrate
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?
additional information
?
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MCD expression plays a key reciprocal role in the balance between lipid and glucose metabolism, MCD silencing increases glucose uptake in myotubes
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?
additional information
?
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docking analysis of the enzyme onto peroxin 5. modeling, overview
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-
?
additional information
?
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docking analysis of the enzyme onto peroxin 5. modeling, overview
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?
additional information
?
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MCD is an inhibitor of carnitine palmitoyl-CoA transferase-1
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-
?
