4.1.1.9: malonyl-CoA decarboxylase

This is an abbreviated version!
For detailed information about malonyl-CoA decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.9

4.1.1.9

carnitine

malonic

amp-activated

palmitoyltransferase

aciduria

goose

uropygial

methylmalonyl-coa

methylmalonic

medicine

Reaction

Synonyms

Acyl-CoA: malonate CoA transferase/malonyl-CoA decarboxylase, Decarboxylase, malonyl coenzyme A, hMCD, malonyl CoA decarboxylase, Malonyl coenzyme A decarboxylase, Malonyl-CoA decarboxylase, malonyl-CoA decarboxylase/acetyltransferase, malonyl-coenzyme A decarboxylase, MCD, MLYCD

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.9 malonyl-CoA decarboxylase

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Results	in table
16	Activating Compound
323	AA Sequence
6	Application
1	CAS Registry Number
19	Cloned(Commentary)
1	Cofactor
7	Crystallization (Commentary)
180	Disease/ Diagnostics
21	General Information
2	General Stability
276	IC50 Value
584	Inhibitors
15	kcat/KM [mM/s]
2	Ki Value [mM]
41	KM Value [mM]
44	Localization
2	Metals/Ions
43	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
102	Organism
9	Pathway
20	PDB ID
26	pH Optimum
5	pH Range
2	pI Value
8	Posttranslational Modification
25	Protein Variants
26	Purification (Commentary)
3	Reaction
3	Reaction Type
88	Reference
59	Source Tissue
22	Specific Activity [micromol/min/mg]
1	Storage Stability
121	Substrates and Products (Substrate)
24	Subunits
60	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
17	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 4.1.1.9 - malonyl-CoA decarboxylase

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0.000376

((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000105

((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00008

((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00029

(2E)-3-(5-methyl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazol-3-yl)prop-2-enenitrile

Rattus norvegicus

678604

0.00014

(2E)-3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]prop-2-enenitrile

Rattus norvegicus

678604

0.000118

(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one O-ethyloxime

Rattus norvegicus

678604

0.000152

(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one oxime

Rattus norvegicus

678604

0.00035

(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime

Rattus norvegicus

678604

0.000044

(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime

Rattus norvegicus

678604

0.000627

(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000034

(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00045

1,1,1,3,3,3-hexafluoro-2-(2-phenoxy-1,3-thiazol-5-yl)propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000016

1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(2H-tetrazol-2-yl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000024

1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.00024 - 0.00032

1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol

2 entries

0.000044

1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.00011

1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000057

1,1,1,3,3,3-hexafluoro-2-(2-[[4-(trifluoromethyl)phenyl]sulfonyl]-1,3-thiazol-5-yl)propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000209

1,1,1,3,3,3-hexafluoro-2-(4-[(5E)-2-(1-methylethyl)-5-[(phenylperoxy)imino]-4,5-dihydro-1H-imidazol-1-yl]phenyl)propan-2-ol

Rattus norvegicus

678604

0.000149

1,1,1,3,3,3-hexafluoro-2-(4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol

Rattus norvegicus

678604

0.000274

1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)propan-2-ol

Rattus norvegicus

678604

0.000114

1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl)propan-2-ol

Rattus norvegicus

678604

0.000465

1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenoxy)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol

Rattus norvegicus

678604

0.000037

1,1,1,3,3,3-hexafluoro-2-[2-(1-phenylpiperidin-4-yl)-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.00002

1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperazin-1-yl)-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000013

1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperidin-1-yl)-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000092

1,1,1,3,3,3-hexafluoro-2-[2-[(4-methylphenyl)sulfanyl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000036

1,1,1,3,3,3-hexafluoro-2-[2-[1-(3-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000019

1,1,1,3,3,3-hexafluoro-2-[2-[1-(4-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000016

1,1,1,3,3,3-hexafluoro-2-[2-[4-(2-fluorophenyl)-4-(2H-tetrazol-2-yl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000087

1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000011

1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000046

1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000012

1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000081

1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000076

1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000059

1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000089

1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0006

1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfanyl]phenyl]propan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000155

1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol

Rattus norvegicus

678604

0.000116

1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol

Rattus norvegicus

678604

0.00034

1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol

Rattus norvegicus

678604

0.00006

1,3-diethyl-3-(4-hydroxybutyl)-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000037

1,3-dimethyl-1-(2-methylpropyl)butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate

Rattus norvegicus

681284

0.00009

1,3-dimethyl-1-(2-methylpropyl)butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate

Rattus norvegicus

681284

0.000005

1-ethyl-1-methylpropyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate

Rattus norvegicus

681284

0.000007

1-ethyl-1-methylpropyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate

Rattus norvegicus

681284

0.000059

1-ethyl-3,3-dimethyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00006

1-ethyl-3-(4-hydroxybutyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea

Rattus norvegicus

678604

0.000059

1-ethyl-3-methyl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea

Rattus norvegicus

678604

0.001564

1-methyl-3-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00633

1-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.0000033

1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000045

1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidin-4-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000011

1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carbonitrile

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000049

1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxamide

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000011

1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxylic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000009

1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-(methylsulfonyl)-4-phenylpiperidine-4-carboxamide

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000047

1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-methyl-4-phenylpiperidine-4-carboxamide

Homo sapiens

pH and temperature not specified in the publication

714415

0.0059

1-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00658

1-[5-(2,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00365

1-[5-(2,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00768

1-[5-(2,4-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-l]ethanone

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00026

1-[5-(3,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00347

1-[5-(3,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00442

1-[5-(4-chlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.05

1-[5-(4-hydroxyphenyl)-3-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Homo sapiens

O95822

IC50 above 0.05 mM, at pH 8.0 and 30°C

748540

0.00697

1-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00328

2,2,2-trifluoro-1-[4-(pyrrolidin-1-ylcarbonyl)phenyl]ethanone

Rattus norvegicus

678643

0.0000133

2-(4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.00046

2-(4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Rattus norvegicus

678604

0.000303

2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Rattus norvegicus

678604

0.0002

2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide

Rattus norvegicus

678604

0.000059

2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol

Rattus norvegicus

678604

0.000225

2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid

Rattus norvegicus

678604

0.000042

2-methyl-N-(pyridin-4-ylmethyl)-N-[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]propanamide

Rattus norvegicus

678604

0.00545

2-methyl-N-[4-(trifluoroacetyl)phenyl]propanamide

Rattus norvegicus

678643

0.006626

2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]acetamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.0015

2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide

Rattus norvegicus

678643

0.0000017

2-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.000074

2-[2-(1-methylpropyl)-5-propyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]ethenone

Rattus norvegicus

678604

0.000011

2-[2-[4-(3,4-difluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000032

2-[2-[4-(3-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.000079

2-[2-[4-(3-chlorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000027

2-[2-[4-(4-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.00225

2-[3-(4-hydroxyphenyl)-5-(4-methoxy-2-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00355

2-[3-(4-hydroxyphenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.0016

2-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00203

2-[3-(4-hydroxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00041

2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol

Rattus norvegicus

678604

0.0000051

2-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.00765

2-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00204

2-[5-(2,4-dinitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00027

2-[5-(3,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00308

2-[5-(3,5-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00152

2-[5-(4-bromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00192

2-[5-(4-nitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.0001

2-[5-(furan-3-yl)-3-(4-hydroxy-3,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00223

2-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.00234

2-[5-(pyridin-2-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Homo sapiens

O95822

at pH 8.0 and 30°C

748540

0.000247

3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid

2 entries

0.000099

3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester

2 entries

0.00034

3-(1-methylethyl)-N-pyridin-4-yl-4(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide

Rattus norvegicus

678604

0.00042

3-(1-methylethyl)-N-[(2E)-3-phenylprop-2-en-1-yl]-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide

Rattus norvegicus

678604

0.0028

3-(2-methylpropyl)-1-propyl-1-[4-(trifluoroacetyl)phenyl]urea

Rattus norvegicus

678643

0.00008

3-nitrophenyl 3-[(2-methylpropyl)(phenylcarbonyl)amino]propaneperoxoyl-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.004337

3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.0000031

3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]-N-methylbenzamide

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000018

3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzamide

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000009

3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.000239

3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]propanoic acid

Rattus norvegicus

678604

0.000163

3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid

Rattus norvegicus

678604

0.0000005

3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000023

3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]-N-methylbenzamide

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000022

3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzamide

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000013

3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.000016

3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile

Homo sapiens

pH and temperature not specified in the publication

714415

0.000014

3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]benzamide

Homo sapiens

pH and temperature not specified in the publication

714415

0.000075

4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester

2 entries

0.0000133

4-(2-amino-1,3-thiazol-4-yl)-7-[[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]sulfanyl]-2H-chromen-2-ol

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000006

4-(3-carboxyphenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000014

4-(4-fluorophenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.000507

4-(trifluoroacetyl)-N-[3-(trifluoromethyl)phenyl]benzamide

Rattus norvegicus

678643

0.000037

4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide

2 entries

0.0049

4-cyano-N-[4-(trifluoroacetyl)phenyl]benzamide

Rattus norvegicus

678643

0.0000004

4-cyclohexyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.0000034

4-cyclopropyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.000004

4-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.000019

4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid

Homo sapiens

pH and temperature not specified in the publication

714415

0.000042

4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile

Homo sapiens

pH and temperature not specified in the publication

714415

0.000014

5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000042

5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester

2 entries

0.000008

5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid

2 entries

0.00002 - 0.000026

5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester

3 entries

0.00039

5-methyl-N-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-3-carboxamide

Rattus norvegicus

678604

0.000107

5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile

Rattus norvegicus

678604

0.000168

6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile

Rattus norvegicus

678604

0.000318

ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazole-4-carboxylate

Rattus norvegicus

678604

0.000037

ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate

Rattus norvegicus

678604

0.000191

ethyl 2-pyridin-4-yl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazole-4-carboxylate

Rattus norvegicus

678604

0.000463

ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate

Rattus norvegicus

681284

0.000421

ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate

Rattus norvegicus

681284

0.001767

ethyl [((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]acetate

Rattus norvegicus

681284

4.1

L-malate

Homo sapiens

in 40 mM Tris, pH 8.0

690405

0.000088

methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]prop-2-enoate

Rattus norvegicus

678604

0.000065

methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate

Rattus norvegicus

678604

0.000041

methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate

Rattus norvegicus

678604

0.000054

methyl 4-[(2-methylpropanoyl)[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]amino]benzoate

Rattus norvegicus

678604

0.00114

morpholin-4-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000166

morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.00004

morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.00003

morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.000074

morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.000073

morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.000031

morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.000321

morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.000269

morpholine-4-carboxylic acid octyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000019

morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.000043

morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.000034

morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide

2 entries

0.000073

N,N-bis(2-methylpropyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.001619

N,N-diethyl-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.00007

N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide

2 entries

0.000153

N,N-dipropyl-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678604, 678643

0.000242

N-(1,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678604, 678643

0.00025

N-(1-methylethyl)-3-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide

Rattus norvegicus

678604

0.003361

N-(1-methylethyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000801

N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide

Rattus norvegicus

681284

0.000137

N-(1-methylethyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide

Rattus norvegicus

681284

0.001731

N-(1-methylethyl)-N-phenyl-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000115

N-(1-methylhexyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.00029

N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide

2 entries

0.000214

N-(2-cyanoethyl)-N-ethyl-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678604, 678643

0.000155

N-(2-cyanoethyl)-N-phenoxy-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678604, 678643

0.001147

N-(2-dimethylaminoethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000106

N-(2-hydroxyethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000304

N-(2-methylcyclohexyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000068

N-(2-methylcyclopropyl)-N-propyl-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.001531

N-(2-methylpropyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000566

N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678604, 678643

0.002753

N-(3,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000489

N-(3,3-dimethylbutyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide

Rattus norvegicus

681284

0.001351

N-(3-phenoxypropyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000028

N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide

Rattus norvegicus

681284

0.00002

N-(4-cyanobutyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00002

N-(4-cyanophenyl)-2-methyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)propanamide

Rattus norvegicus

678604

0.00039

N-(4-cyanophenyl)-3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide

Rattus norvegicus

678604

0.001739

N-(4-phenoxybutyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000028

N-(6-methylheptyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide

Rattus norvegicus

681284

0.000304 - 0.002298

N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide

2 entries

0.000117

N-(cyclopropylmethyl)-6-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]pyridine-3-carboxamide

Rattus norvegicus

678604

0.002034

N-(furan-2-ylmethyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.00058

N-benzyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.001

N-benzyl-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000079

N-butyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000177

N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)acetamide

Rattus norvegicus

678604

0.000111

N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)pyridine-4-carboxamide

Rattus norvegicus

678604

0.00002

N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide

2 entries

0.00015

N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide

2 entries

0.000175

N-ethyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000399

N-ethyl-N-(2-hydroxy-2-methylpropyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.001105

N-ethyl-N-(2-methoxyethyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000041

N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide

2 entries

0.000095

N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide

2 entries

0.00006

N-heptyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide

Rattus norvegicus

681284

0.000679

N-hexyl-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000199

N-isopropyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00145

N-methoxy-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00093

N-methyl-2-phenoxy-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)acetamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.0045

N-methyl-2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide

Rattus norvegicus

678643

0.000814

N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide

Homo sapiens

in 40 mM Tris, pH 8.0

690405

0.000773

N-methyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000676

N-methyl-N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide

Rattus norvegicus

681284

0.000953

N-methyl-N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000394

N-methyl-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)pyridine-4-carboxamide

Rattus norvegicus

678604

0.00199

N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000178

N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide

2 entries

0.000394

N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.001015

N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]nicotinamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00265

N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl) benzamide

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000028

N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide

2 entries

0.005011

N-[(2-hydroxyphenoxy)methyl]-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000654

N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoroacetyl)benzamide

Rattus norvegicus

678643

0.000017

N-[3-[bis(1-methylethyl)amino]-3-oxopropyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide

Rattus norvegicus

681284

0.000008

N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide

2 entries

0.0172

N-[4-(trifluoroacetyl)phenyl]morpholine-4-carboxamide

Rattus norvegicus

678643

2.2

NAD+

Homo sapiens

in 40 mM Tris, pH 8.0

690405

0.00098

piperidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.00085

pyrrolidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone

Homo sapiens

in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4

681279

0.000008

tert-butyl (3R)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate

Rattus norvegicus

681284

0.000168

tert-butyl (3R)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate

Rattus norvegicus

681284

0.00001

tert-butyl (3R)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate

Rattus norvegicus

681284

0.000045

tert-butyl (3R)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate

Rattus norvegicus

681284

0.000005

tert-butyl (3S)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate

Rattus norvegicus

681284

0.000136

tert-butyl (3S)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate

Rattus norvegicus

681284

0.000007

tert-butyl (3S)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate

Rattus norvegicus

681284

0.000009

tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate

Homo sapiens

in 40 mM Tris, pH 8.0

690405

0.000015

tert-butyl (3S)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate

Rattus norvegicus

681284

0.000023

tert-butyl 3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate

Rattus norvegicus

681284

0.000031

tert-butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate

Rattus norvegicus

681284

0.00003

tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate

Rattus norvegicus

681284

0.000113

tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)leucinate

Rattus norvegicus

681284