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4.1.1.9: malonyl-CoA decarboxylase

This is an abbreviated version!
For detailed information about malonyl-CoA decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.9

Reaction

malonyl-CoA
=
acetyl-CoA
+
CO2

Synonyms

Acyl-CoA: malonate CoA transferase/malonyl-CoA decarboxylase, Decarboxylase, malonyl coenzyme A, hMCD, malonyl CoA decarboxylase, Malonyl coenzyme A decarboxylase, Malonyl-CoA decarboxylase, malonyl-CoA decarboxylase/acetyltransferase, malonyl-coenzyme A decarboxylase, MCD, MLYCD

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.9 malonyl-CoA decarboxylase

Activating Compound

Activating Compound on EC 4.1.1.9 - malonyl-CoA decarboxylase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
-
AMP-activated protein kinase activator, 2fold activation of MCD in extensor digitorum longus, reversed by protein phosphatase A
Alkaline phosphatase
-
treatment with alkaline phosphatase enhances MCD activity suggesting phosphorylation-related control of enzyme
-
AMP-activated potein kinase
-
AMP-activated potein kinase activates MCD by phosphorylation
-
DL-carnitine
-
stimulates
fatty acid
-
increases MCD expression in heart and skeletal muscle
fenofibrate
-
increases hepatic mRNA expression and MCD activity
iodoacetamide
palmitate
-
the activity of MCD elicits a dose-dependent increase (between 25% and 60%) in cells exposed to increasing concentrations of palmitate (0.1-0.8 mM)
phosphate
-
activates
WY-14643
-
specifically stimulates the peroxisome proliferator-activated receptor-alpha increasing MCD expression and activity in heart and skeletal muscle
additional information
-