4.1.1.9: malonyl-CoA decarboxylase
This is an abbreviated version!
For detailed information about malonyl-CoA decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.9
-
4.1.1.9
-
carnitine
-
malonic
-
amp-activated
-
palmitoyltransferase
-
aciduria
-
goose
-
uropygial
-
methylmalonyl-coa
-
methylmalonic
-
medicine
- 4.1.1.9
- carnitine
-
malonic
-
amp-activated
- palmitoyltransferase
-
aciduria
- goose
-
uropygial
- methylmalonyl-coa
-
methylmalonic
- medicine
Reaction
Synonyms
Acyl-CoA: malonate CoA transferase/malonyl-CoA decarboxylase, Decarboxylase, malonyl coenzyme A, hMCD, malonyl CoA decarboxylase, Malonyl coenzyme A decarboxylase, Malonyl-CoA decarboxylase, malonyl-CoA decarboxylase/acetyltransferase, malonyl-coenzyme A decarboxylase, MCD, MLYCD
ECTree
Advanced search results
Activating Compound
Activating Compound on EC 4.1.1.9 - malonyl-CoA decarboxylase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
-
AMP-activated protein kinase activator, 2fold activation of MCD in extensor digitorum longus, reversed by protein phosphatase A
Alkaline phosphatase
-
treatment with alkaline phosphatase enhances MCD activity suggesting phosphorylation-related control of enzyme
-
AMP-activated potein kinase
-
AMP-activated potein kinase activates MCD by phosphorylation
-
palmitate
-
the activity of MCD elicits a dose-dependent increase (between 25% and 60%) in cells exposed to increasing concentrations of palmitate (0.1-0.8 mM)
WY-14643
-
specifically stimulates the peroxisome proliferator-activated receptor-alpha increasing MCD expression and activity in heart and skeletal muscle
-
malonyl-decarboxylase activity is induced by treatment of fatty acid synthetase with iodoacetamide
iodoacetamide
-
treatment of fatty acid synthetase with iodoacetamide induces malonyl-CoA decarboxylase activity and impairs the synthetase activity
-
there is an age-dependent increase in expression of MCD manifesting maturation of fatty acid metabolism in the newborn human heart
-
additional information
-
gastrocnemius contraction activates MCD, reversed by protein phosphatase A or by omitting phosphatase inhibitors from assay mixture, increase of MCD activity after skeletal muscle contraction is likely due to its phosphorylation by AMP-activated protein kinase
-
additional information
-
high-fat feeding, fasting and streptozotocin-induced diabetes increase the plasma concentration of nonesterified fatty acids, with a concomitant increase in both heart and skeletal muscle MCD mRNA
-
additional information
-
MCD activity is elevated under conditions in which hepatic fatty acid oxidation is known to increase, such as streptozotocin-induced diabetes or following a 48 h fast, 2fold increase in expression in streptozotocin-diabetic rats compared with controls
-
additional information
-
peroxisomal-proliferator-activated receptor alpha activates transcription of hepatic MCD gene by binding of peroxisomal-proliferator-activated receptor alpha/retinoid X receptor alpha on two PPRE sites, WY14643-treated H4IIE hepatoma cells show increased MCD mRNA expression
-