4.1.1.88: biotin-independent malonate decarboxylase
This is an abbreviated version!
For detailed information about biotin-independent malonate decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.88
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4.1.1.88
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malonomonas
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rubra
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prosthetic
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pneumoniae
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klebsiella
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malonyl-coa
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malonylation
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citrate
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thioester
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acinetobacter
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calcoaceticus
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transacylase
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acyl-carrier
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malonyl-coa:acp
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dithioerythritol
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avidin
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epsilon
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hydroxylamine
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anhydride
- 4.1.1.88
-
malonomonas
- rubra
-
prosthetic
- pneumoniae
-
klebsiella
- malonyl-coa
-
malonylation
- citrate
- thioester
-
acinetobacter
- calcoaceticus
-
transacylase
-
acyl-carrier
-
malonyl-coa:acp
- dithioerythritol
- avidin
- epsilon
- hydroxylamine
- anhydride
Reaction
Synonyms
biotin-independent malonate decarboxylase, malonate decarboxylase, malonate decarboxylase (without biotin), MdcACDE
ECTree
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Subunits
Subunits on EC 4.1.1.88 - biotin-independent malonate decarboxylase
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multimer
tetramer
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1 * 65000, alpha subunit, 1* 34000, beta-subunit, 1 * 30000, gamma subunit, 1 * 12000, delta subunit, SDS-PAGE
additional information
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2 * 65000, alpha subunit, 1 * 32000, beta subunit, 1 * 25000, gamma subunit
multimer
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2 * 65000, alpha subunit, 1 * 32000, beta subunit, 1 * 25000, gamma subunit, 1 * 11000, delta subunit
multimer
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2 * 65000, alpha subunit, 1 * 33000, beta subunit, 1 * 30000, gamma subunit, 1 * 11000, delta subunit
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enzyme complex is formed by subunits alpha, beta, gamma, delta. The mdcA gene product, the alpha subunit, is malonate/acetyl-CoA transferase and the mdcD gene product, the beta subunit, is malonyl-CoA decarboxylase. The mdcE gene product, the gamma subunit, may play a role in subunit interaction to form a stable complex or as a codecarboxylase. The mdcC gene product, the delta subunit, is an acyl-carrier protein
additional information
O54414; O54416; O54417; O54415
mdcA gene encodes the alpha subunit carrying acyl carrier protein transferase activity. The mdcD gene encodes the delta subunit, the acyl carrier protein. mdcB encodes the beta subunit, the catalytic subunit of decarboxylation of malonate. The mdcC gene encodes the gamma subunit involved in decarboxylation of the malonyl-S-acyl carrier protein
additional information
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mdcA gene encodes the alpha subunit carrying acyl carrier protein transferase activity. The mdcD gene encodes the delta subunit, the acyl carrier protein. mdcB encodes the beta subunit, the catalytic subunit of decarboxylation of malonate. The mdcC gene encodes the gamma subunit involved in decarboxylation of the malonyl-S-acyl carrier protein
additional information
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enzyme complex is formed by subunits alpha, beta, gamma, delta. The mdcA gene product, the alpha subunit, is malonate/acetyl-CoA transferase and the mdcD gene product, the beta subunit, is malonyl-CoA decarboxylase. The mdcE gene product, the gamma subunit, may play a role in subunit interaction to form a stable complex or as a codecarboxylase. The mdcC gene product, the delta subunit, is an acyl-carrier protein
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additional information
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enzyme is encoded by a gene cluster consisting of the eight consecutive genes mdcABCDEFCH and the divergently oriented mdcR gene. The mdcA, C, D and E genes encode subunits alpha, beta, gamma and delta of malonate decarboxylase. MdcA represents the ACP-transferase and that MdcD and E together probably function as malonyl-S-acyl carrier protein decarboxylase. MdcC is the (apo) acyl carrier protein subunit. MdcB and MdcG are involved in the synthesis and attachment of the prosthetic group. MdcH is probably involved in the initial activation of the enzyme by malonylation. MdcF is a membrane protein that could function as a malonate carrier
additional information
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presence of two forms of the enzyme: a catalytically inactive SH-enzyme and the catalytically active acetyl-S-enzyme which is formed by post-translational acetylation of the SH-enzyme with ATP, acetate and a specific ligase. the delta subunit is the acyl carrier protein of the enzyme complex
additional information
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subunit acyl carrier protein contains a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group attached via a phosphodiester to residue S25. Formation of this phosphodiester bond is catalyzed by a phosphoribosyl-dephospho-coenzyme A transferase MdcG. Site-directed mutagenesis of D134 and/or D136 of MdcG to alanine abolishes the transfer of the prosthetic group to apo acyl carrier protein