Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.1.1.84: D-dopachrome decarboxylase

This is an abbreviated version!
For detailed information about D-dopachrome decarboxylase, go to the full flat file.

Reaction

D-dopachrome
=
5,6-dihydroxyindole
+
CO2

Synonyms

D-dopachrome tautomerase, D-DT, D-tautomerase, DDT, phenylpyruvate tautomerase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.84 D-dopachrome decarboxylase

Reference

Reference on EC 4.1.1.84 - D-dopachrome decarboxylase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Odh, G.; Hindemith, A.; Rosengren, A-M.; Rosengren, E.; Rorsman, H.
Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole
Biochem. Biophys. Res. Commun.
197
619-624
1993
Rattus norvegicus (P80254)
Manually annotated by BRENDA team
Nishihira, J.; Fujinaga, M.; Kuriyama, T.; Suzuki, M.; Sugimoto, H.; Nakagawa, A.; Tanaka, I.; Sakai, M.
Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation
Biochem. Biophys. Res. Commun.
243
538-544
1998
Homo sapiens (P30046)
Manually annotated by BRENDA team
Yoshida, H.; Nishihira, J.; Suzuki, M.; Hikichi, K.
NMR characterization of physicochemical properties of rat D-dopachrome tautomerase
Biochem. Mol. Biol. Int.
42
891-899
1997
Rattus norvegicus (P80254)
Manually annotated by BRENDA team
Sugimoto, H.; Taniguchi, M.; Nakagawa, A.; Tanaka, I.; Suzuki, M.; Nishihira, J.
Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution
Biochemistry
38
3268-3279
1999
Homo sapiens (P30046)
Manually annotated by BRENDA team
Kuriyama T.;Fujinaga M.;Koda T.;Nishihira J.
Cloning of the mouse gene for D-dopachrome tautomerase.
Biochim. Biophys. Acta
1388
506-512
1998
Mus musculus (O35215)
Manually annotated by BRENDA team
Bjoerk, P.; Aman, P.; Hindemith, A.; Odh, G.; Jacobsson, L.; Rosengren, E.; Rorsman, H.
A new enzyme activity in human blood cells and isolation of the responsible protein (D-dopachrome tautomerase) from erythrocytes
Eur. J. Haematol.
57
254-256
1996
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Sonesson, B.; Rosengren, E.; Hansson, A.S.; Hansson, C.
UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor
Exp. Dermatol.
12
278-282
2003
Homo sapiens (P30046)
Manually annotated by BRENDA team
Sugimoto, H.; Taniguchi, M.; Nakagawa, A.; Tanaka, I.; Suzuki, M.; Nishihira, J.
Crystallization and preliminary x-ray analysis of human D-dopachrome tautomerase
J. Struct. Biol.
120
105-108
1997
Homo sapiens (P30046)
Manually annotated by BRENDA team
Rosengren, E.; Thelin, S.; Aman, P.; Hansson, C.; Jacobsson, L.; Rorsman, H.
The protein catalysing the conversion of D-dopachrome to 5,6-dihydroxyindole is a phenylpyruvate tautomerase (EC 5.3.2.1)
Melanoma Res.
7
517-518
1997
Rattus norvegicus
Manually annotated by BRENDA team
Coleman, A.M.; Rendon, B.E.; Zhao, M.; Qian, M.W.; Bucala, R.; Xin, D.; Mitchell, R.A.
Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase
J. Immunol.
181
2330-2337
2008
Mus musculus (O35215), Homo sapiens (P30046)
Manually annotated by BRENDA team
Hiyoshi, M.; Konishi, H.; Uemura, H.; Matsuzaki, H.; Tsukamoto, H.; Sugimoto, R.; Takeda, H.; Dakeshita, S.; Kitayama, A.; Takami, H.; Sawachika, F.; Kido, H.; Arisawa, K.
D-Dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride
Toxicology
255
6-14
2009
Rattus norvegicus
Manually annotated by BRENDA team
Garai, J.; Lorand, T.
Macrophage migration inhibitory factor (MIF) tautomerase inhibitors as potential novel anti-inflammatory agents: current developments
Curr. Med. Chem.
16
1091-1114
2009
Homo sapiens
Manually annotated by BRENDA team