4.1.1.82: phosphonopyruvate decarboxylase

This is an abbreviated version!
For detailed information about phosphonopyruvate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.82

4.1.1.82

phosphoenolpyruvate

thiamin

wedmorensis

bialaphos

2-aminoethylphosphonate

phosphomutase

pep

fosfomycin

hygroscopicus

sulfopyruvate

bacteroides

fragilis

phosphonate

abscess

broth

phosphinothricin

Reaction

Synonyms

PnPy decarboxylase, Ppd, PPDC, Ppyr decarboxylase

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.82 phosphonopyruvate decarboxylase

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Results	in table
755	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
4	Cofactor
2	Inhibitors
1	Ki Value [mM]
12	KM Value [mM]
7	Metals/Ions
9	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
10	Organism
12	Pathway
1	pH Range
15	Protein Variants
3	Purification (Commentary)
1	Reaction
8	Reference
2	Storage Stability
13	Substrates and Products (Substrate)
9	Subunits
7	Synonyms
1	Systematic Name
8	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.1.1.82 - phosphonopyruvate decarboxylase

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3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming)

The enzyme catalyses a step in the biosynthetic pathway of 2-aminoethylphosphonate, a component of the capsular polysaccharide complex of Bacteroides fragilis. Requires thiamine diphosphate and Mg2+ as cofactors. The enzyme is activated by the divalent cations Mg2+, Ca2+ and Mn2+. Pyruvate and sulfopyruvate can also act as substrates, but more slowly. This enzyme drives the reaction catalysed by EC 5.4.2.9, phosphoenolpyruvate mutase, in the thermodynamically unfavourable direction of 3-phosphonopyruvate formation [2]. It is the initial step in all of the major biosynthetic pathways of phosphonate natural products [3].