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4.1.1.8: oxalyl-CoA decarboxylase

This is an abbreviated version!
For detailed information about oxalyl-CoA decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.8

Reaction

oxalyl-CoA
=
formyl-CoA
 +
CO2

Synonyms

Decarboxylase, oxalyl coenzyme A, ODC, oxalyl CoA decarboxylase, Oxalyl coenzyme A decarboxylase, oxalyl-coenzyme A decarboxylase, OXC, yfdU

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.8 oxalyl-CoA decarboxylase

Engineering

Engineering on EC 4.1.1.8 - oxalyl-CoA decarboxylase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E121A
0.1% activity compared to the wild type enzyme
E121Q
3.8% activity compared to the wild type enzyme
E56A
no activity, mutant elutes with a retention time corresponding to that of a dimer
R555A
96% activity compared to the wild type enzyme
S553A
15% activity compared to the wild type enzyme
Y120A
0.3% activity compared to the wild type enzyme
Y120F
8.2% activity compared to the wild type enzyme
Y483A
1.6% activity compared to the wild type enzyme
Y483F
1.9% activity compared to the wild type enzyme
additional information
deletion mutant DELTA553-565 shows almost no activity