4.1.1.77: 2-oxo-3-hexenedioate decarboxylase

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For detailed information about 2-oxo-3-hexenedioate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.77

4.1.1.77

hydratase

catechols

4-hydroxy-2-oxovalerate

2-hydroxymuconic

tautomerase

putida

meta-cleavage

aldolase

acetaldehyde

2-hydroxy-2,4-pentadienoate

stereochemical

2-aminophenols

dehydrogenative

meta-fission

xylf

d2o

2-aminomuconate

extradiol

6-semialdehyde

metal-dependent

fumarylacetoacetate

synthesis

Reaction

Synonyms

4-OD, 4-oxalocrotonate decarboxylase, 4OD, Decarboxylase, 4-oxalocrotonate, NahK, Oxalocrotonate decarboxylase

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.77 2-oxo-3-hexenedioate decarboxylase

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Results	in table
654	AA Sequence
2	Application
1	CAS Registry Number
4	Cloned(Commentary)
1	Crystallization (Commentary)
17	Inhibitors
5	kcat/KM [mM/s]
9	Ki Value [mM]
9	KM Value [mM]
2	Metals/Ions
4	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
42	Organism
23	Pathway
9	PDB ID
2	Protein Variants
3	Purification (Commentary)
4	Reaction
1	Reaction Type
17	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
29	Substrates and Products (Substrate)
3	Subunits
13	Synonyms
1	Systematic Name
9	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.1.1.77 - 2-oxo-3-hexenedioate decarboxylase

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(3E)-2-oxohex-3-enedioate carboxy-lyase (2-oxopent-4-enoate-forming)

Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enzyme has been reported to accept multiple tautomeric forms [1-4]. However, careful analysis of the stability of the different tautomers, as well as characterization of the enzyme that produces its substrate, EC 5.3.2.6, 2-hydroxymuconate tautomerase, showed that the actual substrate for the enzyme is (3E)-2-oxohex-3-enedioate [4].