4.1.1.74: indolepyruvate decarboxylase

This is an abbreviated version!
For detailed information about indolepyruvate decarboxylase, go to the full flat file.

Reaction

Synonyms

Decarboxylase, indolepyruvate, Decarboxylase, indolepyruvate (Enterobacter agglomerans clone pMB2 gene ipdC reduced), GenBank L80006-derived protein GI 1507711, Indole-3-pyruvate decarboxylase, indole-3-pyruvic acid decarboxylase, Indolepyruvate decarboxylase, Indolepyruvate decarboxylase (Enterobacter herbocola strain 299R clone pMB2 gene ipdC reduced), Indolepyruvic acid decarboxylase, IpdC, Ipyr, IPyr decarboxylase, KivD

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.74 indolepyruvate decarboxylase

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Results	in table
6	Activating Compound
690	AA Sequence
2	Application
2	CAS Registry Number
8	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
4	Expression
6	General Information
5	General Stability
8	Inhibitors
4	kcat/KM [mM/s]
3	Ki Value [mM]
41	KM Value [mM]
5	Metals/Ions
14	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
48	Organism
8	Pathway
4	PDB ID
4	pH Optimum
1	pH Stability
7	Protein Variants
5	Purification (Commentary)
5	Reaction
1	Reaction Type
32	Reference
9	Specific Activity [micromol/min/mg]
2	Storage Stability
57	Substrates and Products (Substrate)
11	Subunits
35	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Temperature Stability [°C]
21	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.1.1.74 - indolepyruvate decarboxylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(indol-3-yl)pyruvate

(indole-3-yl)acetaldehyde + CO2

Azospirillum brasilense

P51852

-

690484

-

-

?

(indole-3-yl)pyruvate

(indole-3-yl)acetaldehyde + CO2

Paenibacillus polymyxa E681

-

-

693596

-

-

?

2-oxoglutarate

?

2 entries

2-oxoisovalerate

?

2 entries

3-(indol-3-yl)pyruvate

(indole-3-yl)acetaldehyde + CO2

Azospirillum brasilense

P51852

-

692100

-

-

?

3-(indol-3-yl)pyruvate

2-(indol-3-yl)acetaldehyde + CO2

7 entries

3-(Indol-3-yl)pyruvate

?

8 entries

3-(Indol-3-yl)pyruvate

Indole-3-acetaldehyde + CO2

7 entries

4-bromo-benzoylformic acid

4-bromobenzaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

4-chloro-benzoylformic acid

4-chlorobenzaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

4-ethyl-benzoylformic acid

4-ethylbenzaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

4-fluoro-benzoylformic acid

4-fluorobenzaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

4-hydroxyphenylpyruvate

(4-hydroxyphenyl)acetaldehyde + CO2

2 entries

4-methoxy-benzoylformic acid

4-methoxybenzaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

4-methyl-benzoylformic acid

4-methylbenzaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

4-nitro-benzoylformic acid

4-nitrobenzaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

benzaldehyde

?

Sulfolobus sp.

-

-

651291

-

651291

?

benzoylformate

benzaldehyde + CO2

2 entries

benzoylformic acid

benzaldehyde + CO2

2 entries

glyceraldehyde

?

Sulfolobus sp.

-

-

651291

-

651291

?

indole-3-acetaldehyde

?

2 entries

phenylacetaldehyde

?

Sulfolobus sp.

-

-

651291

-

651291

?

phenylpyruvate

phenylethanal + CO2

Sulfolobus sp.

-

-

651291

-

-

?

pyruvate

acetaldehyde + CO2

6 entries

pyruvic acid

acetaldehyde + CO2

Enterobacter cloacae

-

decarboxylation at 19% of the indole-3-acetic acid decarboxylation

4826

-

-

?

2-oxoglutarate

?

Sulfolobus sp.

-

-

651291

-

651291

?

2-oxoglutarate

?

Sulfolobus sp. 7

-

-

651291

-

651291

?

2-oxoisovalerate

?

Sulfolobus sp.

-

-

651291

-

651291

?

2-oxoisovalerate

?

Sulfolobus sp. 7

-

-

651291

-

651291

?

3-(indol-3-yl)pyruvate

2-(indol-3-yl)acetaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

3-(indol-3-yl)pyruvate

2-(indol-3-yl)acetaldehyde + CO2

Enterobacter cloacae

-

-

664109, 728107

-

-

?

3-(indol-3-yl)pyruvate

2-(indol-3-yl)acetaldehyde + CO2

Enterobacter cloacae ATCC 13047

-

-

728107

-

-

?

3-(indol-3-yl)pyruvate

2-(indol-3-yl)acetaldehyde + CO2

Methylorubrum extorquens

C5ARG4

3-(indol-3-yl)pyruvate is decarboxylated with the highest catalytic efficiency (kcat/Km)

714125

-

-

?

3-(indol-3-yl)pyruvate

2-(indol-3-yl)acetaldehyde + CO2

Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1

C5ARG4

3-(indol-3-yl)pyruvate is decarboxylated with the highest catalytic efficiency (kcat/Km)

714125

-

-

?

3-(indol-3-yl)pyruvate

2-(indol-3-yl)acetaldehyde + CO2

Sulfolobus sp.

-

-

651291

-

651291

?

3-(indol-3-yl)pyruvate

2-(indol-3-yl)acetaldehyde + CO2

Sulfolobus sp. 7

-

-

651291

-

651291

?

3-(Indol-3-yl)pyruvate

?

Azospirillum brasilense

-

upregulation of expression by indole-3-acetic acid and synthetic auxins

4825

-

-

?

3-(Indol-3-yl)pyruvate

?

Azospirillum brasilense

-

enzyme is involved in indole-3-acetic acid synthesis

4825

-

-

?

3-(Indol-3-yl)pyruvate

?

Enterobacter cloacae

-

key enzyme for indole-3-acetic acid biosynthesis

4826, 4827

-

-

?

3-(Indol-3-yl)pyruvate

?

Enterobacter cloacae

-

rate-limiting step in the indole-3-pyruvic acid pathway

4827

-

-

?

3-(Indol-3-yl)pyruvate

?

Pantoea agglomerans

-

a mutant defective in this enzyme is significantly reduced in indole-3-acetic acid production

4824

-

-

?

3-(Indol-3-yl)pyruvate

?

Pantoea agglomerans

-

enzyme is involved in indole-3-acetic acid synthesis

4824

-

-

?

3-(Indol-3-yl)pyruvate

?

Pantoea agglomerans 299R

-

a mutant defective in this enzyme is significantly reduced in indole-3-acetic acid production

4824

-

-

?

3-(Indol-3-yl)pyruvate

?

Pantoea agglomerans 299R

-

enzyme is involved in indole-3-acetic acid synthesis

4824

-

-

?

3-(Indol-3-yl)pyruvate

Indole-3-acetaldehyde + CO2

Azospirillum brasilense

-

-

4823

-

4823

?

3-(Indol-3-yl)pyruvate

Indole-3-acetaldehyde + CO2

Azospirillum brasilense

-

-

4825

-

4825

?

3-(Indol-3-yl)pyruvate

Indole-3-acetaldehyde + CO2

Azospirillum brasilense Sp7

-

-

4823

-

4823

?

3-(Indol-3-yl)pyruvate

Indole-3-acetaldehyde + CO2

Enterobacter cloacae

-

-

4826

-

4826

?

3-(Indol-3-yl)pyruvate

Indole-3-acetaldehyde + CO2

Enterobacter cloacae

-

-

4827

-

4827

?

3-(Indol-3-yl)pyruvate

Indole-3-acetaldehyde + CO2

Pantoea agglomerans

-

-

4824

-

4824

?

3-(Indol-3-yl)pyruvate

Indole-3-acetaldehyde + CO2

Pantoea agglomerans 299R

-

-

4824

-

4824

?

4-hydroxyphenylpyruvate

(4-hydroxyphenyl)acetaldehyde + CO2

Methylorubrum extorquens

C5ARG4

-

714125

-

-

?

4-hydroxyphenylpyruvate

(4-hydroxyphenyl)acetaldehyde + CO2

Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1

C5ARG4

-

714125

-

-

?

benzoylformate

benzaldehyde + CO2

Methylorubrum extorquens

C5ARG4

the enzyme shows the highest kcat value for benzoylformate

714125

-

-

?

benzoylformate

benzaldehyde + CO2

Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1

C5ARG4

the enzyme shows the highest kcat value for benzoylformate

714125

-

-

?

benzoylformic acid

benzaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

benzoylformic acid

benzaldehyde + CO2

Enterobacter cloacae

-

-

664109

-

-

?

indole-3-acetaldehyde

?

Sulfolobus sp.

-

-

651291

-

651291

?

indole-3-acetaldehyde

?

Sulfolobus sp. 7

-

-

651291

-

651291

?

pyruvate

acetaldehyde + CO2

Enterobacter cloacae

-

-

651152

-

651152

?

pyruvate

acetaldehyde + CO2

Enterobacter cloacae

-

-

664109

-

-

?

pyruvate

acetaldehyde + CO2

Methylorubrum extorquens

C5ARG4

-

714125

-

-

?

pyruvate

acetaldehyde + CO2

Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1

C5ARG4

-

714125

-

-

?

pyruvate

acetaldehyde + CO2

Sulfolobus sp.

-

-

651291

-

651291

?

pyruvate

acetaldehyde + CO2

Sulfolobus sp. 7

-

-

651291

-

651291

?