4.1.1.64: 2,2-dialkylglycine decarboxylase (pyruvate)

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For detailed information about 2,2-dialkylglycine decarboxylase (pyruvate), go to the full flat file.

Word Map on EC 4.1.1.64

4.1.1.64

pyridoxal

transamination

aldimine

half-reaction

phosphate-dependent

alkali

stereoelectronic

2-aminoisobutyrate

plp-dependent

r-factors

aminotransferases

cepacia

phenol-lyase

1-aminocyclopropane-1-carboxylate

quinonoid

decarboxylases

toney

pyridoxamine

alpha-carboxylate

omega-amino

Reaction

Synonyms

2,2-Dialkyl-2-amino acid-pyruvate aminotransferase, alpha-Dialkyl amino acid transaminase, alpha-Dialkylamino acid aminotransferase, alpha-Dialkylamino acid transaminase, Decarboxylase, dialkyl amino acid (pyruvate), DGD, Dialkylamino-acid decarboxylase (pyruvate), dialkylglycine decarboxylase, L-Alanine-alpha-ketobutyrate aminotransferase

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.64 2,2-dialkylglycine decarboxylase (pyruvate)

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Results	in table
355	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
7	Cofactor
7	Crystallization (Commentary)
30	Inhibitors
5	Ki Value [mM]
22	KM Value [mM]
19	Metals/Ions
6	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
26	Organism
16	PDB ID
2	pH Optimum
2	pH Range
4	Protein Variants
5	Purification (Commentary)
9	Reaction
2	Reaction Type
26	Reference
1	Source Tissue
4	Specific Activity [micromol/min/mg]
64	Substrates and Products (Substrate)
4	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
23	Turnover Number [1/s]

Engineering

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Engineering on EC 4.1.1.64 - 2,2-dialkylglycine decarboxylase (pyruvate)

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Q52A

Burkholderia cepacia

P16932

85fold decrease in turnover number for decarboxylation half-reaction with 2-aminoisobutyrate and pyruvate, greatly reduced rate of transamination half-reaction and impaired pyridoxamine phosphate binding

661182

Q52E

Burkholderia cepacia

P16932

10000fold decrease in turnover number for decarboxylation half-reaction with 2-aminoisobutyrate and pyruvate, transamination rate is nearly identical to wild-type value

661182

Q52I

Burkholderia cepacia

P16932

100000fold decrease in turnover number for decarboxylation half-reaction with 2-aminoisobutyrate and pyruvate, greatly reduced rate of transamination half-reaction and impaired pyridoxamine phosphate binding

661182

additional information

2 entries