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4.1.1.64: 2,2-dialkylglycine decarboxylase (pyruvate)

This is an abbreviated version!
For detailed information about 2,2-dialkylglycine decarboxylase (pyruvate), go to the full flat file.

Word Map on EC 4.1.1.64

Reaction

2,2-dialkylglycine
+
pyruvate
=
dialkyl ketone
 +
CO2
 +
L-alanine

Synonyms

2,2-Dialkyl-2-amino acid-pyruvate aminotransferase, alpha-Dialkyl amino acid transaminase, alpha-Dialkylamino acid aminotransferase, alpha-Dialkylamino acid transaminase, Decarboxylase, dialkyl amino acid (pyruvate), DGD, Dialkylamino-acid decarboxylase (pyruvate), dialkylglycine decarboxylase, L-Alanine-alpha-ketobutyrate aminotransferase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.64 2,2-dialkylglycine decarboxylase (pyruvate)

Crystallization

Crystallization on EC 4.1.1.64 - 2,2-dialkylglycine decarboxylase (pyruvate)

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure at 2.8 A resolution of tzhe enzyme with Li+ or Rb+ bound
-
crystal structures at 2.8 A resolution with Li+ and Rb+ bound at the binding site for alkali metal ions which is close to the active site, i.e. site 1
-
hanging drop vapor diffusion method, crystal structure of Q52A mutant and wild-type enzyme in complex with pyridoxamine 5'-phosphate
in complex with different aminophosphonate inhibitors
in complex with four inhibitors