4.1.1.61: 4-hydroxybenzoate decarboxylase

This is an abbreviated version!
For detailed information about 4-hydroxybenzoate decarboxylase, go to the full flat file.

Reaction

Synonyms

4-hydroxybenzoate DC, 4-hydroxybenzoate decarboxylase, Decarboxylase, p-hydroxybenzoate, HBDC, KpdB, p-Hydroxybenzoate decarboxylase, Phenol carboxylase, vanillate/4-hydroxybenzoate decarboxylase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.61 4-hydroxybenzoate decarboxylase

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Results	in table
2	Activating Compound
231	AA Sequence
5	Application
1	CAS Registry Number
3	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
3	General Stability
31	Inhibitors
21	KM Value [mM]
2	Localization
34	Metals/Ions
8	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
37	Organism
2	Oxidation Stability
4	Pathway
25	PDB ID
13	pH Optimum
1	pH Range
2	pH Stability
1	pI Value
3	Purification (Commentary)
4	Reaction
2	Reaction Type
21	Reference
3	Source Tissue
17	Specific Activity [micromol/min/mg]
2	Storage Stability
51	Substrates and Products (Substrate)
3	Subunits
10	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
6	Temperature Stability [°C]
2	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.1.1.61 - 4-hydroxybenzoate decarboxylase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2,3,4-Trihydroxybenzoate

3 entries

2,4,6-Trihydroxybenzoate

3 entries

2,4-Dihydroxybenzoate

3 entries

3,4,5-Trihydroxybenzoate

3 entries

3-Chloro-4-hydroxybenzoate

2 entries

Co2+

2 entries

CuCl2

Enterobacter cloacae

-

2.5 mM, 91% loss of activity

677849

CuSO4

Enterobacter cloacae

-

2.5 mM, 92% loss of activity

677849

EDTA

4 entries

HgCl2

Enterobacter cloacae

-

2.5 mM, 78% loss of activity

677849

m-Hydroxybenzoylhydrazine dichloride

2 entries

NH4+

Sedimentibacter hydroxybenzoicus

-

decreases carboxylation of 3,4-dihydroxybenzoate by about 20%

4740

Rb+

Sedimentibacter hydroxybenzoicus

-

decreases carboxylation of 3,4-dihydroxybenzoate by about 20%

4740

Sodium dithionite

2 entries

Zn2+

Sedimentibacter hydroxybenzoicus

-

destroys carboxylation activity towards 4-hydroxybenzoate and 3,4-dihydroxybenzoate

4740

additional information

Enterobacter cloacae

-

not significantly affected by phenylhydrazine or hydroxylamine

677849

-

2,3,4-Trihydroxybenzoate

Desulfovibrio sp.

-

complete inhibition of carboxylation of phenol

4741

2,3,4-Trihydroxybenzoate

Methanospirillum hungatei

-

complete inhibition of carboxylation of phenol

4741

2,3,4-Trihydroxybenzoate

Sedimentibacter hydroxybenzoicus

-

-

4740

2,4,6-Trihydroxybenzoate

Desulfovibrio sp.

-

complete inhibition of carboxylation of phenol

4741

2,4,6-Trihydroxybenzoate

Methanospirillum hungatei

-

complete inhibition of carboxylation of phenol

4741

2,4,6-Trihydroxybenzoate

Sedimentibacter hydroxybenzoicus

-

-

4740

2,4-Dihydroxybenzoate

Desulfovibrio sp.

-

-

4741

2,4-Dihydroxybenzoate

Methanospirillum hungatei

-

-

4741

2,4-Dihydroxybenzoate

Sedimentibacter hydroxybenzoicus

-

-

4740

3,4,5-Trihydroxybenzoate

Desulfovibrio sp.

-

slight inhibition of carboxylation of phenol

4741

3,4,5-Trihydroxybenzoate

Methanospirillum hungatei

-

slight inhibition of carboxylation of phenol

4741

3,4,5-Trihydroxybenzoate

Sedimentibacter hydroxybenzoicus

-

-

4740

3-Chloro-4-hydroxybenzoate

Desulfovibrio sp.

-

-

4741

3-Chloro-4-hydroxybenzoate

Methanospirillum hungatei

-

-

4741

Co2+

Desulfovibrio sp.

-

-

4741

Co2+

Methanospirillum hungatei

-

-

4741

EDTA

Desulfovibrio sp.

-

-

4741

EDTA

Enterobacter cloacae

-

2.5 mM, 22% inhibition

677849

EDTA

Methanospirillum hungatei

-

-

4741

EDTA

uncultured bacterium

-

47% inhibition at 5 mM, Mg2+, Mn2+, Zn2+ or Ca2+ protect, Fe2+ does not

650756

m-Hydroxybenzoylhydrazine dichloride

Desulfovibrio sp.

-

-

4741

m-Hydroxybenzoylhydrazine dichloride

Methanospirillum hungatei

-

-

4741

Sodium dithionite

Desulfovibrio sp.

-

-

4741

Sodium dithionite

Methanospirillum hungatei

-

-

4741