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4.1.1.5: acetolactate decarboxylase

This is an abbreviated version!
For detailed information about acetolactate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.5

Reaction

(2S)-2-hydroxy-2-methyl-3-oxobutanoate
=
(3R)-3-hydroxybutan-2-one
 +
CO2

Synonyms

ADC, ALD, aldB, ALDC, alpha-Acetolactate decarboxylase, AlsD, BudA1, Decarboxylase, acetolactate

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.5 acetolactate decarboxylase

Inhibitors

Inhibitors on EC 4.1.1.5 - acetolactate decarboxylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R,3R)-[(2R)-3-hydroxy-2-(hydroxy-kappaO)-2-methylbutanoic acid-kappaO]zinc(2+)
competitive inhibition of the transition state analogue
(2R,3S)-[(2R)-3-hydroxy-2-(hydroxy-kappaO)-2-methylbutanoic acid-kappaO]zinc(2+)
mixed inhibition of the transition state analogue
(2S,3R)-[(2S)-3-hydroxy-2-(hydroxy-kappaO)-2-methylbutanoic acid-kappaO]zinc(2+)
competitive inhibition of the transition state analogue
(2S,3S)-[(2S)-3-hydroxy-2-(hydroxy-kappaO)-2-methylbutanoic acid-kappaO]zinc(2+)
competitive inhibition of the transition state analogue
1,10-phenanthroline
2-phosphoglyceric acid
-
alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
3-Phosphoglyceric acid
-
alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
6-phosphogluconic acid
-
alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
8-Quinolinol
-
-
ADP
-
alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
ATP
-
alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
diethyldithiocarbamate
-
-
dihydroxyacetone phosphate
-
alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
EDTA
-
2 mM Mn2+ restores 82% of the activity, 2 mM Zn2+ restores 69% of the initial activity
fructose 1,6-diphosphate
-
alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
p-hydroxymercuribenzoate
-
-
phosphoenolpyruvate
-
alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
Trinitrobenzenesulfonate
-
weak
additional information
-