4.1.1.48: indole-3-glycerol-phosphate synthase

This is an abbreviated version!
For detailed information about indole-3-glycerol-phosphate synthase, go to the full flat file.

Word Map on EC 4.1.1.48

4.1.1.48

sulfolobus

solfataricus

amidotransferase

chorismate

prfar

n-5'-phosphoribosylanthranilate

on-pathway

glutamine-dependent

betaalpha8-barrel

betaalpha8

medicine

drug development

Reaction

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Synonyms

eIGPS, IGP synthase, IGPS, indole-3-glycerol phosphate synthase, Indole-3-glycerol phosphate synthetase, Indole-3-glycerol-phosphate synthase, indole-3-glycerolphosphate synthase, Indole-3-glycerophosphate synthase, Indoleglycerol phosphate synthase, Indoleglycerol phosphate synthetase, Indoleglycerolphosphate synthetase, InGP synthase, InGP synthetase, InGPS, mIGPS, MtIGPS, Phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Pk-trpC, PRAI, PRAI-InGPS, sIGPS, SSO0895, Synthase, indole-3-glycerol phosphate, TrpC

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.48 indole-3-glycerol-phosphate synthase

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Results	in table
41425	AA Sequence
5	Application
1	CAS Registry Number
12	Cloned(Commentary)
10	Crystallization (Commentary)
3	Expression
5	General Information
6	General Stability
15	Inhibitors
43	kcat/KM [mM/s]
1	Ki Value [mM]
89	KM Value [mM]
4	Metals/Ions
48	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
301	Organism
6	Pathway
46	PDB ID
7	pH Optimum
3	pH Range
3	pH Stability
1	Posttranslational Modification
69	Protein Variants
20	Purification (Commentary)
4	Reaction
1	Reaction Type
82	Reference
1	Renatured (Commentary)
2	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
109	Substrates and Products (Substrate)
22	Subunits
77	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Range [°C]
20	Temperature Stability [°C]
59	Turnover Number [1/s]

Purification

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Purification on EC 4.1.1.48 - indole-3-glycerol-phosphate synthase

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10 entries

bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase

2 entries

chromatographic purification, Phenyl Sepharose High Sub FF column, ultrafiltration membrane (molecular weight cutoff) of 10,000 Da, Sephacryl S-100 column

Mycobacterium tuberculosis

701916

final step with Superdex-75 gel filtration

Saccharolobus solfataricus

681434

monofunctional enzyme

Escherichia coli

4611

multifunctional enzyme with the activities of Ec 4.1.4.27, Ec 4.2.2.18, Ec 4.1.1.48 and Ec 4.2.1.20

Euglena gracilis

4603

Ni-NTA His-binding resin affinity chromatography

Mycobacterium tuberculosis

678351

Q-Sepharose column chromatography

Escherichia coli

726866

TALON metal affinity resin column chromatography

Pseudomonas aeruginosa

728750